LP99 - CAS 1808951-93-0
Catalog number: 1808951-93-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H30ClN3O4S
Molecular Weight:
516.05
COA:
Inquire
Targets:
BET Bromodomain
Description:
LP99 is the first selective BRD7/9 bromodomain inhibitor. The effect of LP99 on IL-6 expression demonstrates for the first time that a small-molecule BRD7/9 inhibitor may have a similar function and utility to IL-6 neutralizing antibodies, such as tocilizumab, in the treatment of rheumatoid arthritis.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Solid powder
Synonyms:
N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide N-((2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamide N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide GTPL8572 LP99
MSDS:
Inquire
InChIKey:
LVDRREOUMKACNJ-BKMJKUGQSA-N
InChI:
1S/C26H30ClN3O4S/c1-16(2)15-35(33,34)28-22-11-12-24(31)30(26(22)18-5-7-19(27)8-6-18)20-9-10-21-17(3)13-25(32)29(4)23(21)14-20/h5-10,13-14,16,22,26,28H,11-12,15H2,1-4H3/t22-,26+/m0/s1
Canonical SMILES:
CC1=CC(=O)N(C2=C1C=CC(=C2)N3C(C(CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related BET Bromodomain Products


CAS 1869912-40-2 AZD5153 6-Hydroxy-2-naphthoic acid

AZD5153 6-Hydroxy-2-naphthoic acid
(CAS: 1869912-40-2)

AZD5153 6-Hydroxy-2-naphthoic acid, a 6-hydroxy-2-naphthoic acid salt of AZD-5153, is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor p...

CAS 1300031-49-5 I-BET151

I-BET151
(CAS: 1300031-49-5)

I-BET151, also known as GSK1210151A, is a BET bromodomain inhibitor, which blocks recruitment of BET to chromatin. I-BET151 (GSK1210151A) shows good oral bioava...

CAS 1268524-70-4 JQ-1

JQ-1
(CAS: 1268524-70-4)

JQ-1, a selective BET bromodomain inhibitor with antiproliferative activity, is highly active against human leukemia OCI-AML3 mutation lines such as nucleophosm...

GSK6853
(CAS: 1910124-24-1)

GSK6853 is a potent (pKd 9.5), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain with greater than 1600-fold selectivity ov...

Mivebresib
(CAS: 1445993-26-9)

Mivebresib is a BET inhibitor with potential antineoplastic activity. It disrupts critical transcription programs that drive prostate cancer growth to induce po...

CAS 2070014-93-4 PF-CBP1 HCl

PF-CBP1 HCl
(CAS: 2070014-93-4)

PF-CBP1, also known as PF-06670910, is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively) with more than 100-fold selectivity ...

CAS 1044870-39-4 RVX-208

RVX-208
(CAS: 1044870-39-4)

RVX-208 is a potent inhibitor of BET bromodomains. RVX-208 functions by removing atherosclerotic plaque via reverse cholesterol transport (RCT). RVX-208 increas...

PFI-3
(CAS: 1819363-80-8)

PFI-3, a potent and selective SMARCA2/4 bromodomain inhibitor, is a cell-permeable probe that binds avidly to the structurally-similar SMARCA4 bromodomain (Kd= ...

CAS 1949837-12-0 ARV-771

ARV-771
(CAS: 1949837-12-0)

ARV-771, a pan-BET degrader, is a novel BET-PROTAC with superior in vivo pharmacology that recruits the E3 ligase VHL (Von Hippel-Lindau) to degrade BETPs (Kd= ...

I-BRD9
(CAS: 1714146-59-4)

I-BRD9, as a selective cell active chemical probe for BRD9 (pIC50 = 7.3), it exhibits 200-fold selectivity for bromodomain containing protein 9 over the highly ...

CAS 1800340-40-2 BMS-986158

BMS-986158
(CAS: 1800340-40-2)

BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins with potential antineoplastic activity.

BET-BAY 002
(CAS: 1588521-78-1)

BET-BAY 002 is a potent BET inhibitor with strong in vitro and in vivo activities in AML and MM models, and with excellent pharmacokinetic properties.

CAS 936091-14-4 TG101209

TG101209
(CAS: 936091-14-4)

TG101209 is a novel and potent JAK2 inhibitor. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosi...

CAS 1268524-71-5 (R)-(-)-JQ1

(R)-(-)-JQ1
(CAS: 1268524-71-5)

The (R) - isomer form of JQ1 which is a BET inhibitor that could probably influence the inflammatory expression at some extent.

CAS 1619994-69-2 Bromosporine

Bromosporine
(CAS: 1619994-69-2)

Bromosporine, a broad spectrum inhibitor for bromodomains which play a key role in many cellular processes, is a chemical probe for bromodomain functional assay...

GSK 525768A
(CAS: 1260530-25-3)

GSK 525768A is a enantiomer analogue of GSK 525762A which is a BET family inhibitor aiming at the bromodomain and has potential effect against cancers and sorts...

PFI-4
(CAS: 900305-37-5)

PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.

LP99
(CAS: 1808951-93-0)

LP99 is the first selective BRD7/9 bromodomain inhibitor. The effect of LP99 on IL-6 expression demonstrates for the first time that a small-molecule BRD7/9 in...

CAS 1300031-52-0 GSK1324726A (I-BET726)

GSK1324726A (I-BET726)
(CAS: 1300031-52-0)

GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), ...

CAS 1883429-22-8 BI-9564

BI-9564
(CAS: 1883429-22-8)

BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 µM, respectively), with selectivity for ...

Quick Inquiry

Verification code

Featured Items