LP99 - CAS 1808951-93-0
Catalog number:
1808951-93-0
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H30ClN3O4S
Molecular Weight:
516.05
COA:
Inquire
Targets:
BET Bromodomain
Description:
LP99 is the first selective BRD7/9 bromodomain inhibitor. The effect of LP99 on IL-6 expression demonstrates for the first time that a small-molecule BRD7/9 inhibitor may have a similar function and utility to IL-6 neutralizing antibodies, such as tocilizumab, in the treatment of rheumatoid arthritis.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Solid powder
Synonyms:
N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide N-((2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamide N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide GTPL8572 LP99
MSDS:
Inquire
InChIKey:
LVDRREOUMKACNJ-BKMJKUGQSA-N
InChI:
1S/C26H30ClN3O4S/c1-16(2)15-35(33,34)28-22-11-12-24(31)30(26(22)18-5-7-19(27)8-6-18)20-9-10-21-17(3)13-25(32)29(4)23(21)14-20/h5-10,13-14,16,22,26,28H,11-12,15H2,1-4H3/t22-,26+/m0/s1
Canonical SMILES:
CC1=CC(=O)N(C2=C1C=CC(=C2)N3C(C(CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related BET Bromodomain Products


CAS 1300031-49-5 I-BET151

I-BET151
(CAS: 1300031-49-5)

I-BET151, also known as GSK1210151A, is a BET bromodomain inhibitor, which blocks recruitment of BET to chromatin. I-BET151 (GSK1210151A) shows good oral b...

CAS 1883429-22-8 BI-9564

BI-9564
(CAS: 1883429-22-8)

BI-9564 is a potent and selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 µM, respectively), with selectivity for ...

PFI-4
(CAS: 900305-37-5)

PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.

PFI-3
(CAS: 1819363-80-8)

PFI-3, a potent and selective SMARCA2/4 bromodomain inhibitor, is a cell-permeable probe that binds avidly to the structurally-similar SMARCA4 bromodomain (Kd= ...

CAS 1869912-40-2 AZD5153 6-Hydroxy-2-naphthoic acid

AZD5153 6-Hydroxy-2-naphthoic acid
(CAS: 1869912-40-2)

AZD5153 6-Hydroxy-2-naphthoic acid, a 6-hydroxy-2-naphthoic acid salt of AZD-5153, is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor p...

CAS 2070014-93-4 PF-CBP1 HCl

PF-CBP1 HCl
(CAS: 2070014-93-4)

PF-CBP1, also known as PF-06670910, is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively) with more than 100-fold selectivity ...

CAS 936091-14-4 TG101209

TG101209
(CAS: 936091-14-4)

TG101209 is a novel and potent JAK2 inhibitor. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosi...

CAS 1395084-25-9 MS436

MS436
(CAS: 1395084-25-9)

MS436 exhibits low nanomolar affinity with preference for the first bromodomain over the second.

BET-BAY 002
(CAS: 1588521-78-1)

BET-BAY 002 is a potent BET inhibitor with strong in vitro and in vivo activities in AML and MM models, and with excellent pharmacokinetic properties.

GSK 525768A
(CAS: 1260530-25-3)

GSK 525768A is a enantiomer analogue of GSK 525762A which is a BET family inhibitor aiming at the bromodomain and has potential effect against cancers and sorts...

BET-IN-1
(CAS: 1422554-34-4)

BET-IN-1, an oxazole derivative, can be used as a bromodomain inhibitor

CAS 202590-98-5 OTX015

OTX015
(CAS: 202590-98-5)

OTX015 a potent BET bromodomian inhibitor, which targets the BET bromodomain proteins 2, 3, and 4 (BRD). BRDs 2, 3, and 4 are considered potential cancer target...

CAS 936091-26-8 TG101348

TG101348
(CAS: 936091-26-8)

CAS 755038-02-9 BI-2536

BI-2536
(CAS: 755038-02-9)

BI-2563 is a small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arr...

I-BRD9
(CAS: 1714146-59-4)

I-BRD9, as a selective cell active chemical probe for BRD9 (pIC50 = 7.3), it exhibits 200-fold selectivity for bromodomain containing protein 9 over the highly ...

BET bromodomain inhibitor
(CAS: 1505453-59-7)

An BET bromodomain inhibitor can be used for the treatment of hematologic malignancies. It binds BET proteins to suppress the interaction between these proteins...

CAS 1446144-04-2 CPI-203

CPI-203
(CAS: 1446144-04-2)

CPI203 inhibits BRD4 in vitro and in cells, while does not affect BRD4 kinase activity in vitro.

LP99
(CAS: 1808951-93-0)

LP99 is the first selective BRD7/9 bromodomain inhibitor. The effect of LP99 on IL-6 expression demonstrates for the first time that a small-molecule BRD7/9 in...

CAS 1260907-17-2 GSK525762

GSK525762
(CAS: 1260907-17-2)

GSK525762A, also known as I-BET-762 and GSK525762, is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing pr...

CAS 919973-83-4 OF-1

OF-1
(CAS: 919973-83-4)

OF-1 is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor with Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, ...

Quick Inquiry

Verification code

Featured Items