LP99 - CAS 1808951-93-0
Catalog number: 1808951-93-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C26H30ClN3O4S
Molecular Weight:
516.05
COA:
Inquire
Targets:
BET Bromodomain
Description:
LP99 is the first selective BRD7/9 bromodomain inhibitor. The effect of LP99 on IL-6 expression demonstrates for the first time that a small-molecule BRD7/9 inhibitor may have a similar function and utility to IL-6 neutralizing antibodies, such as tocilizumab, in the treatment of rheumatoid arthritis.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Appearance:
Solid powder
Synonyms:
N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxoquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide N-((2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl)-2-methylpropane-1-sulfonamide N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,4-dimethyl-2-oxo-1,2-dihydroquinolin-7-yl)-6-oxopiperidin-3-yl]-2-methylpropane-1-sulfonamide GTPL8572 LP99
MSDS:
Inquire
InChIKey:
LVDRREOUMKACNJ-BKMJKUGQSA-N
InChI:
1S/C26H30ClN3O4S/c1-16(2)15-35(33,34)28-22-11-12-24(31)30(26(22)18-5-7-19(27)8-6-18)20-9-10-21-17(3)13-25(32)29(4)23(21)14-20/h5-10,13-14,16,22,26,28H,11-12,15H2,1-4H3/t22-,26+/m0/s1
Canonical SMILES:
CC1=CC(=O)N(C2=C1C=CC(=C2)N3C(C(CCC3=O)NS(=O)(=O)CC(C)C)C4=CC=C(C=C4)Cl)C
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related BET Bromodomain Products


CAS 1800340-40-2 BMS-986158

BMS-986158
(CAS: 1800340-40-2)

BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins with potential antineoplastic activity.

GSK6853
(CAS: 1910124-24-1)

GSK6853 is a potent (pKd 9.5), soluble, cell active (20 nM), and highly selective inhibitor of the BRPF1 bromodomain with greater than 1600-fold selectivity ov...

CAS 936091-14-4 TG101209

TG101209
(CAS: 936091-14-4)

TG101209 is a novel and potent JAK2 inhibitor. The induction of cytotoxicity was associated with inhibition of cell cycle progression and induction of apoptosi...

CAS 1923851-49-3 GSK9311

GSK9311
(CAS: 1923851-49-3)

GSK9311 is a potent and selective inhibitor of the BRPF bromodomain (pIC50= 6.0 and 4.3 for BRPF1 and BRPF2, respectively).

GSK2801
(CAS: 1619994-68-1)

GSK2801 is a A Selective Chemical Probe for BAZ2B/A bromodomains. BAZ2A/B belong to a family of ubiquitously expressed bromodomain containing proteins.probes/GS...

CPI-637
(CAS: 1884712-47-3)

CPI-637 is a selective and cell-active benzodiazepinone CBP/EP300 bromodomain inhibitor with IC50 of 0.03±0.01μM and 11.0±0.6 μM for CBP/EP300 and BRD4, respect...

CAS 717906-29-1 PF-431396

PF-431396
(CAS: 717906-29-1)

PF-431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively).

CAS 1619994-69-2 Bromosporine

Bromosporine
(CAS: 1619994-69-2)

Bromosporine, a broad spectrum inhibitor for bromodomains which play a key role in many cellular processes, is a chemical probe for bromodomain functional assay...

CAS 1300031-52-0 GSK1324726A (I-BET726)

GSK1324726A (I-BET726)
(CAS: 1300031-52-0)

GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), ...

CAS 1403764-72-6 PFI-1

PFI-1
(CAS: 1403764-72-6)

PFI-1 is a potent and highly selective protein interaction Inhibitor, which targets BET bromodomain. PFI-1 that efficiently blocks the interaction of BET BRDs...

CAS 1992047-61-6 NVS-CECR2-1

NVS-CECR2-1
(CAS: 1992047-61-6)

NVS-CECR2-1 is a potent and selective CECR2 (cat eye syndrome chromosome region, candidate 2) inhibitor (IC50 = 47 nM). NVS-CECR2-1 showed no cross reactivity i...

CAS 1395084-25-9 MS436

MS436
(CAS: 1395084-25-9)

MS436 exhibits low nanomolar affinity with preference for the first bromodomain over the second.

Olinone
(CAS: 1770789-37-1)

Olinone, a pyridoindol derivative, has been found to be an BET Bromodomain inhibitor and could be probably useful in sorts of biological studies.

GSK 525768A
(CAS: 1260530-25-3)

GSK 525768A is a enantiomer analogue of GSK 525762A which is a BET family inhibitor aiming at the bromodomain and has potential effect against cancers and sorts...

Mivebresib
(CAS: 1445993-26-9)

Mivebresib is a BET inhibitor with potential antineoplastic activity. It disrupts critical transcription programs that drive prostate cancer growth to induce po...

CPI-0610
(CAS: 1380087-89-7)

CPI-0610, a benzazepine derivative, has been found to influence tumor cell growth at some extent by acting as a BET bromodomain inhibitor. IC50: < 500 nM for BR...

CAS 936091-26-8 TG101348

TG101348
(CAS: 936091-26-8)

CAS 2070014-93-4 PF-CBP1 HCl

PF-CBP1 HCl
(CAS: 2070014-93-4)

PF-CBP1, also known as PF-06670910, is an inhibitor of the CBP and p300 bromodomains (IC50s = 125 and 363 nM, respectively) with more than 100-fold selectivity ...

CAS 1429129-68-9 OXF BD 02

OXF BD 02
(CAS: 1429129-68-9)

OXF BD 02 is a first bromodomain of BRD4 inhibitor with IC50 value of 382 nM. It can reduce viability of lung adenocarcinoma cell lines and attenuate proliferat...

CAS 1962928-21-7 PF-CBP1

PF-CBP1
(CAS: 1962928-21-7)

PF-CBP1, also known as PF-06670910, is a selective CBP/p300 bromodomain inhibitor (IC50 values are 125 and 363 nM, respectively) with >100-fold selectivity for ...

Quick Inquiry

Verification code

Featured Items