LOXO-101 sulfate - CAS 1223405-08-0
Catalog number: 1223405-08-0
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H24F2N6O6S
Molecular Weight:
526.51
COA:
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Targets:
Trk Receptor
Description:
The sulfate salt form of LOXO-101, also called Larotrectinib, is a ATP-competitive inhibitor of tropomyosin receptor kinases and is still under Phase II clinical triall for Solid tumours. IC50: 2 - 20 nM.
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Purity:
95%
Appearance:
Powder
Synonyms:
LOXO-101 (sulfate); Larotrectinib sulfate; ARRY-470 sulfate; LOXO-101 sulfate; UNII-RDF76R62ID; RDF76R62ID
Solubility:
DMSO: ≥ 31 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
The sulfate salt form of LOXO-101 which is a ATP-competitive inhibitor of tropomyosin receptor kinases.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
InChIKey:
PXHANKVTFWSDSG-QLOBERJESA-N
InChI:
InChI=1S/C21H22F2N6O2.H2O4S/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27;1-5(2,3)4/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31);(H2,1,2,3,4)/t14-,18+;/m0./s1
Canonical SMILES:
C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O
Current Developer:
Loxo Oncology
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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