LOXO-101 (ARRY-470) - CAS 1223403-58-4
Catalog number:
1223403-58-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H22F2N6O2
Molecular Weight:
428.44
COA:
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Targets:
TRKA, TRKB, and TRKC
Description:
LOXO-101, also known as ARRY-470, is an orally bioavailable, potent, ATP-competitive inhibitor of TRKA, TRKB, and TRKC. LOXO-101 has IC50 values in the low nanomolar range for inhibition of all three TRK family members in binding and cellular assays, with 100x selectivity over other kinases, and has shown acceptable pharmaceutical properties and safety in nonclinical models.
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Purity:
98%
Appearance:
Solid powder
Synonyms:
LOXO 101; LOXO-101; LOXO101; ARRY-470; ARRY470; ARRY 470.
Solubility:
Soluble in DMSO, not in water
Storage:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years if stored properly
Canonical SMILES:
O=C(N1CC[C@@H](C1)O)NC2=C3N=C(N4CCC[C@@H]4C5=CC(F)=CC=C5F)C=CN3N=C2
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