Loxapine Succinate - CAS 27833-64-3
Catalog number:
27833-64-3
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H18ClN3O.C4H6O4
Molecular Weight:
445.9
COA:
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Targets:
5-HT Receptor
Description:
Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.oxapine is a typical antipsychotic medication, used primarily in the treatment of schizophrenia. Trade names for loxapine taken by mouth include Loxapac and Loxitane; the inhalable form is approved as Adasuve.
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Purity:
>98%
Synonyms:
Loxapine Succinate
MSDS:
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1. Brain Disposition and Catalepsy After Intranasal Delivery of Loxapine: Role of Metabolism in PK/PD of Intranasal CNS Drugs
Yin Cheong Wong & Zhong Zuo. Pharm Res (2013) 30:2368–2384
In the PK/PD study, four to five rats were used for each time point per treatment group. Nasal loxapine solution was prepared by dissolving 7 mg loxapine succinate in 1 ml of 2.5% (w/v) Solutol® HS 15 (BASF Corporation, NJ, USA) in normal saline and the concentration of loxapine (free base) was 5.2 mg/ml. This concentrated solution was diluted 10-fold with normal saline to achieve a loxapine concentration of 0.52 mg/ml for oral administration. The dose of loxapine was 0.3mg/kg. All the drug administration procedures and behavioral tests were conducted in conscious rats.
2. Pharmacotherapy of disorders in mental retardation
M. G. Aman, A. Collier-Crespin, R. L. Lindsay. European Child & Adolescent Psychiatry 9: I/98–I/107
All of the above reports were based on adult samples. Campbell and Gonzalez (17) reviewed the research on antipsychotic drugs in typically developing schizophrenic children and adolescents. Controlled studies are rare. In one comparison study, thiothixene was considered superior to thioridazine in adolescents with chronic schizophrenia. One report based on chart reviews indicated that clozapine was effective in adolescents. Two controlled studies indicated that haloperidol and loxapine succinate were effective in schizophrenic children and adolescents. To the best of our knowledge, there is no database on pharmacotherapy in children and adolescents having both mental retardation and schizophrenia. Faced with this, it seems that clinicians have no choice but to use the standard of care that is applied with nonretarded patients. In the very recent expert consensus survey (27), the novel antipsychotics (exclusive of clozapine) were endorsed most heavily, followed by high-potency classical antipsychotics.
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CAS 27833-64-3 Loxapine Succinate

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