Lovastatin - CAS 75330-75-5
Catalog number: 75330-75-5
Category: Inhibitor
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Molecular Formula:
C24H36O5
Molecular Weight:
404.54
COA:
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Targets:
HMG-CoA Reductase (HMGCR)
Description:
Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM, used for lowering cholesterol (hypolipidemic agent).
Purity:
>98%
Synonyms:
Lovastatin; Mevinolin; Mevacor; Monacolin K; Altoprev; MK 803; MK-803; MK803; Monacolin K; QAB149; QAB149; QAB149
MSDS:
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InChIKey:
PCZOHLXUXFIOCF-BXMDZJJMSA-N
InChI:
InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
Canonical SMILES:
CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
1.Lovastatin corrects ERK pathway hyperactivation in fragile X syndrome: potential of platelet's signaling cascades as new outcome measures in clinical trials.
Pellerin D1, Çaku A1, Fradet M1, Bouvier P1, Dubé J1, Corbin F1. Biomarkers. 2016 Apr 8:1-12. [Epub ahead of print]
AIM: To establish whether platelets from fragile X syndrome (FXS) individuals recapitulate FXS mouse neurons' defects in ERK and Akt pathways, and to evaluate the effect of lovastatin on these pathways.
2.A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I.
Bearden CE1, Hellemann GS1, Rosser T2, Montojo C1, Jonas R3, Enrique N1, Pacheco L1, Hussain SA4, Wu JY4, Ho JS5, McGough JJ1, Sugar CA6, Silva AJ7. Ann Clin Transl Neurol. 2016 Feb 22;3(4):266-79. doi: 10.1002/acn3.288. eCollection 2016.
OBJECTIVE: Lovastatin has been shown to reverse learning deficits in a mouse model of Neurofibromatosis Type 1 (NF1), a common monogenic disorder caused by a mutation in the Ras-MAPK pathway and associated with learning disabilities. We conducted a randomized double-blind placebo-controlled trial to assess lovastatin's effects on cognition and behavior in patients with NF1.
3.Effect of Lovastatin on Wound-Healing Modulation After Glaucoma Filtration Surgery in a Rabbit Model.
Park JH, Yoo C, Kim YY. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):1871-7. doi: 10.1167/iovs.15-19003.
PURPOSE: To investigate the efficacy of lovastatin as an antifibrotic agent after glaucoma filtration surgery (GFS) in a rabbit model.
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CAS 75330-75-5 Lovastatin

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