|Description||Loperamide HCl is an opioid-receptor agonist with an ED50 of 0.15 mg/kg.|
ICI 154,129 is a selective δ opioid antagonist. It is a peptide analog that antagonized the effects of Leu-enkephalin.
Naloxegol is a CYP3A4 enzyme inhibitor. It is also a peripherally-selective opioid antagonist. It is used as the treatment of opioid-induced constipation. lt is...
U-54494A hydrochloride is a κ-opioid agonist and a potential NMDA antagonist. U-54494A hydrochloride is used as an anticonvulsant.
GR 89696 fumarate
GR 89696 fumarate is a potent and selective κ-opioid agonist (IC50 = 0.04 nM) displaying anti-nociceptive and neuroprotective activity.
(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, which is an opioid receptor agonist.
PL 017, a morphiceptin analog, is a selective μ opioid receptor agonist (IC50= 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ a...
[Nphe1]Nociceptin(1-13)NH2 acts as the first truly selective and competitive nociceptin receptor antagonist and is devoid of any residual agonist activity. It b...
FIT is a selective and irreversible δ-opioid (DOR) agonist (EC50 = 8 nM).
NocII, a heptadecapeptide whose sequence lies immediately downstream of nociceptin, stimulates locomotion in mice, possibly through a novel specific receptor.
BW 373U86 is a potent and selective non-peptide δ-opioid receptor agonist (Ki = 1.8, 15 and 34 nM for δ, μ and κ receptors, respectively).
PZM21 is a potent Gi activator with exceptional selectivity for μOR (EC50= 1.8 nM) and minimal β-arrestin-2 recruitment.
Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels.
Cyprodime hydrochloride is a selective μ-opioid receptor antagonist from the morphinan family of drugs. Its Ki values are 5.4, 244.6 and 2187 nM for μ-, δ- and ...
6 α-naloxol, a human metabolite of naloxone, is an opioid antagonist.
nor-Binaltorphimine dihydrochloride is a selective κ-opioid receptor antagonist.
A 4-phenylpiperidine derivative, for the κ-opioid receptor.
ML 190 is a κ opioid receptor antagonist with IC50 value of 120 nM.
[Leu5]-Enkephalin is an endogenous opioid agonist peptide with morphine-like activity. It inhibits electrically stimulated contractions in mouse vas deferens (I...
(±)-U-50488 hydrochloride is a selective κ-opioid agonist with no μ-opioid antagonist effects. (±)-U-50488 hydrochloride blocks Na+ channels at high concentrati...
DIPPA hydrochloride is an irreversible and selective antagonist of κ-opioid receptor (KOR).