Lomustine - CAS 13010-47-4
Catalog number: 13010-47-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
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DNA Alkylator/Crosslinker
Lomustine (420 μM) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively.
Publictions citing BOC Sciences Products
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1.Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort.
Chow EJ1, Stratton KL2, Leisenring WM2, Oeffinger KC3, Sklar CA3, Donaldson SS4, Ginsberg JP5, Kenney LB6, Levine JM7, Robison LL8, Shnorhavorian M9, Stovall M10, Armstrong GT8, Green DM8. Lancet Oncol. 2016 Mar 22. pii: S1470-2045(16)00086-3. doi: 10.1016/S1470-2045(16)00086-3. [Epub ahead of print]
BACKGROUND: The effect of many contemporary chemotherapeutic drugs on pregnancy and livebirth is not well established. We aimed to establish the effects of these drugs on pregnancy in male and female survivors of childhood cancer not exposed to pelvic or cranial radiotherapy.
2.Lomustine Nanoparticles Enable Both Bone Marrow Sparing and High Brain Drug Levels - A Strategy for Brain Cancer Treatments.
Fisusi FA1, Siew A1, Chooi KW1, Okubanjo O1, Garrett N2, Lalatsa K1, Serrano D1, Summers I2, Moger J2, Stapleton P1, Satchi-Fainaro R3, Schätzlein AG1,4, Uchegbu IF5,6. Pharm Res. 2016 May;33(5):1289-303. doi: 10.1007/s11095-016-1872-x. Epub 2016 Feb 22.
PURPOSE: The blood brain barrier compromises glioblastoma chemotherapy. However high blood concentrations of lipophilic, alkylating drugs result in brain uptake, but cause myelosuppression. We hypothesised that nanoparticles could achieve therapeutic brain concentrations without dose-limiting myelosuppression.
3.Phase 2 study of concurrent radiotherapy and temozolomide followed by temozolomide and lomustine in the treatment of children with high-grade glioma: a report of the Children's Oncology Group ACNS04
Jakacki RI1, Cohen KJ1, Buxton A1, Krailo MD1, Burger PC1, Rosenblum MK1, Brat DJ1, Hamilton RL1, Eckel SP1, Zhou T1, Lavey RS1, Pollack IF1. Neuro Oncol. 2016 Mar 22. pii: now038. [Epub ahead of print]
BACKGROUND: The prognosis for children with malignant glioma is poor. This study was designed to determine whether lomustine and temozolomide following radiotherapy and concurrent temozolomide improves event-free survival (EFS) compared with historical controls with anaplastic astrocytoma (AA) or glioblastoma (GBM) and whether survival is influenced by the expression of O6-methylguanine-DNA-methyltransferase (MGMT).
4.A case of Takotsubo cardiomyopathy after chemotherapy.
Malley T1, Watson E1. Oxf Med Case Reports. 2016 Apr 7;2016(4):55-8. doi: 10.1093/omcr/omw014. eCollection 2016.
Here we present the case of a patient with diffuse large B-cell lymphoma who was admitted to hospital for an elective autologous peripheral blood stem cell transplant after cytotoxic treatment with lomustine, cytarabine, cyclophosphomide and etoposide (LACE). On the final day of chemotherapeutic treatment, she developed sudden onset dyspnoea. Electrocardiography confirmed acute antero-lateral T-wave inversion. She went onto have coronary angiography that demonstrated unobstructed coronary arteries. Left ventriculography demonstrated apical ballooning, consistent with Takotsubo (stress) cardiomyopathy. The link between chemotherapy and Takotsubo cardiomyopathy has become increasingly recognized in recent years, although causality remains to be established and the mechanism of action is not yet fully understood.
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CAS 13010-47-4 Lomustine

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