Lomibuvir - CAS 1026785-55-6
Catalog number: 1026785-55-6
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C25H35NO4S
Molecular Weight:
445.62
COA:
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Targets:
NS5B polymerase
Description:
Lomibuvir is an nonnucleoside NS5B polymerase inhibitor. It inhibits the 1b/Con1 HCV subgenomic replicon. It binds to the HCV polymerase with dissociation constants of 17 nM. It demonstrated effective antiviral efficacy and may be used for the treatment of HCV. It was developed by ViroChem Pharma, which was acquired by Vertex Pharmaceuticals in 2009. It is in clinical phase 2 with no progress.
Purity:
>98 %
Appearance:
Solid powder
Synonyms:
5-(3,3-Dimethyl-1-butynyl)-3-[(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]thiophene-2-carboxylic acid;VX-222;VX222;VCH-222;VCH222
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Lomibuvir demonstrated effective antiviral efficacy and may be used for the treatment of HCV.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Boiling Point:
640.5±55.0 °C | Condition: Press: 760 Torr
Density:
1.21±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
WPMJNLCLKAKMLA-UHFFFAOYSA-N
InChI:
InChI=1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30)
Canonical SMILES:
CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
Current Developer:
Lomibuvir was developed by ViroChem Pharma, which was acquired by Vertex Pharmaceuticals in 2009. It is in clinical phase 2 with no progress.
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