Lometrexol - CAS 106400-81-1
Catalog number:
106400-81-1
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
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Description:
Lometrexol is a folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation. The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate.
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Synonyms:
Lometrexol; LMTX; LY 264618;
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Current Developer:
Tularik
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CAS 106400-81-1 Lometrexol

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