|Targets||Akt | ERK | Trk Receptor|
|Description||LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, which activates hippocampal and striatal TrkB and TrkC, and their downstream signaling, and increased hippocampal dendritic spine density.|
|Solubility||DMSO: ≥ 150 mg/mL|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
|Boiling Point||718.9±60.0 ℃ at 760 Torr|
AX 15836 is a highly potent and selective ERK5 inhibitor with an IC50 of 8 nM. It is selective for ERK5 over a panel of over 200 kinases. It also displays selec...
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LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, which activates hippocampal and striatal TrkB and TrkC, and their downstream signaling, and increas...
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Sodium Tauroursodeoxycholate (TUDC)
Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.
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ANA-12 is a selective TrkB antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and T...
This active molecular is a selective pan-TRK inhibitor. GNE-8525 shows potent antiproliferation activity (IC50 = 0.003 μM) and it shows in vivo antitumor effica...
GNF 5837 is a potent and selective pan-Trk inhibitor that blocks tumor gowth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF. GNF...
SC66 is a novel and potent AKT inhibitor, which reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in...
LY3214996 is a highly selective and orally available inhibitor of ERK1 an dERK2 (IC50= 5 nM for both enzymes in biochemical assays)and thereby preventing the ac...
Ulixertinib, also known as BVD-523 and VRT752271 is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Upon oral administration, BVD-523...