Limonin - CAS 1180-71-8
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.
Publictions citing BOC Sciences Products
  • >> More
1. Triterpenoids
Joseph D. Connolly and Robert A. Hill*. Nat. Prod. Rep., 2010, 27, 79–132
A review covering the biological activities of the citrus limonoids has been published. 17-epi-Limonin 481 has been reported from a Citrus species. Evolimorutanin 482 from the unripe fruit of Evodia rutaecarpa and methyl uguenenoate 483 from Vepris uguenensis are presumably transformation products of limonin. The obacunol derivatives 484 and 485, the nomilin derivatives 486 and 487 (odoralide) and 8b,14a-dihydroswietenolide 488 are constituents of the stembark of Cedrela odorata.
2. Limonoids and their anti-proliferative and anti-aromatase properties in human breast cancer cells
Jinhee Kim, Guddadarangavvanahally K. Jayaprakasha and Bhimanagouda S. Patil*. Food Funct., 2013, 4, 258–265
The retention time and mass spectra of compounds (1–9) were confirmed and matched to our previously reported values. Based on the HPLC and mass spectral data, compounds 1–9 were identified and characterized as obacunone, nomilin, limonin, limonexic acid (LNA), isolimonexic acid (ILNA), obacunone glucoside (OG), nomilinic acid glucoside (NAG), deacetyl nomilinic acid glucoside (DNAG), and limonin glucoside (LG), respectively. The structures of purified limonoids were presented in Fig. 3. The modifiied compounds such as DL, LM, LO, and DN were prepared using purified limonin and nomilin and used for biological activities.
3. Citrus limonoids and curcumin additively inhibit human colon cancer cells
Kotamballi N. Chidambara Murthy, G. K. Jayaprakasha* and Bhimanagouda S. Patil*. Food Funct., 2013, 4, 803–810
Limonoids are colorless tetracyclic triterpenoids, which are found in citrus fruits with relatively higher concentrations in the seed compared to the juice. Limonin, the most abundant limonoid from citrus is an oxygenated compound known to possess various biological activities including larvicidal activity against the mosquito Culex quinquefasciatus, and suppression of coronary heart disease markers. Our group has characterized and explored several biological activities of citrus limonoids and other phytochemicals with emphasis on cancer chemoprevention. This research in our laboratory has demonstrated inhibition of colon cancer cell proliferation by limonin and other limonoids. In a recent study, we also demonstrated a possible mechanism of apoptosis induction by both limonin and LG in SW480 cells. One of our previous studies demonstrated the ability of citrus limonoids to inhibit leukemia, ovarian, cervical, stomach, liver and breast cancer cells. An animal study has also shown that freeze-dried grapefruit powder, naringin and limonin were capable of inhibiting aberrant crypts through suppression of cyclo-oxy-genase-2 and inducible nitric oxide synthase (iNOS) in an azoxymethane-induced colon cancer model.
4. Metabolomics strategy reveals therapeutical assessment of limonin on nonbacterial prostatitis
Aihua Zhang, Huiyu Wang, Hui Sun, Yue Zhang, Na An, Guangli Yan, Xiangcai Meng and Xijun Wang*. Food Funct.,2015, 6,3540–3549
Limonoids are highly oxygenated, modified terpenoids with a prototypical structure either containing or derived from a precursor with a 4,4,8-trimethyl-17-furanylsteroid skeleton found abundantly in plant families such as Meliaceae and Rutaceae. Limonin (Fig. S1†), also called obaculactone or limonoic acid, is one of the most prevalent limonoids, widely used as a dietary supplement. In 1938, Highby first isolated limonin from Washington navel orange. Ongoing studies show that limonin has exhibited a range of biological activities like antibacterial, antifungal, antimalarial, anticancer, antiviral, antimicrobial, anti-HIV, and a number of other pharmacological activities on humans. Limonin could inhibit chemically induced carcinogenesis and a series of human cancer cell lines, with a remarkable cytotoxicity against lung, colon, oral and skin cancer in animal test and human breast cancer cells. In recent years a large number of pharmacological studies have been carried out to indicate its beneficial effects.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related HIV Products

CAS 957890-42-5 HIV-1 integrase inhibitor 2

HIV-1 integrase inhibitor 2
(CAS: 957890-42-5)

HIV-1 integrase inhibitor 2 is useful for anti-HIV, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other...

CAS 635728-49-3 Darunavir Ethanolate

Darunavir Ethanolate
(CAS: 635728-49-3)

Darunavir Ethanolate is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

CAS 1051375-16-6 Dolutegravir (GSK1349572)

Dolutegravir (GSK1349572)
(CAS: 1051375-16-6)

Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y1...

CAS 136817-59-9 Delavirdine

(CAS: 136817-59-9)

Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of...

CAS 229975-97-7 Atazanavir Sulfate

Atazanavir Sulfate
(CAS: 229975-97-7)

Atazanavir is a HIV protease inhibitor with Ki of 2.66 nM. It is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is ...

CAS 161814-49-9 Amprenavir

(CAS: 161814-49-9)

Amprenavir promotes the specific interactions between the nuclear receptor pregnane X receptor (PXR) and the coactivators SRC-1 and PBP.

CAS 35943-35-2 Triciribine

(CAS: 35943-35-2)

Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/th...

CAS 701213-36-7 BMS-626529

(CAS: 701213-36-7)

BMS-626529 is a member of the new drug class of HIV-1 attachment inhibitors currently in development. BMS-663068 is the phosphonooxymethyl prodrug of BMS-626529...

CAS 226700-81-8 Fosamprenavir Calcium Salt

Fosamprenavir Calcium Salt
(CAS: 226700-81-8)

HIV protease inhibitor; water soluble prodrug of amprenavir.

Ingenol 3-Hexanoate
(CAS: 83036-61-7)

Ingenol 3-Hexanoate, an ingenol-derived compound, was more potent in reactivating latent HIV than other known activators such as SAHA, ingenol 3,20-dibenzoate, ...

(CAS: 1443460-91-0)

GSK2838232, a derivative of Betulin, is a novel human immune virus (HIV) maturation inhibitor being developed for the treatment of chronic HIV infection.

CAS 149845-06-7 Saquinavir Mesylate

Saquinavir Mesylate
(CAS: 149845-06-7)

Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy. It inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at saquinavir as a ...

CAS 174022-42-5 Bevirimat

(CAS: 174022-42-5)

Bevirimat, also known as MPC-4326 and PA-457, is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chine...

CAS 729607-74-3 BMS-707035

(CAS: 729607-74-3)

BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM.

CAS 149488-17-5 Trovirdine

(CAS: 149488-17-5)

Trovirdine, a thiourea non-nucleoside reverse transcriptase inhibitor, was shown to inhibits HIV-1 RT when employing heteropolymeric primer/template (oligo-DNA/...

CAS 7481-89-2 Zalcitabine

(CAS: 7481-89-2)

Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).

CAS 864953-29-7 BMS-663068

(CAS: 864953-29-7)

BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. It is a prodrug for BMS-626529, which binds to the viral envelo...

(CAS: 177577-60-5)

PNU-104489, a sulfonamidoindol derivative, has been found to be a HIV-1 specific inhibitor and was proved to exhibit activity against BHA-P-resistant HIV-1MF ha...

CAS 229005-80-5 TAK-779

(CAS: 229005-80-5)

TAK-779 is a potent, dual antagonist at chemokine receptors CCR2 and CCR5 with IC50 = 1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such ...

(CAS: 634907-30-5)

Censavudine is a nucleoside reverse transcriptase inhibitor. It is active against HIV resistant to both abacavir and tenofovir. It is a candidate for people wit...

Chemical Structure

CAS 1180-71-8 Limonin

Quick Inquiry

Verification code

Featured Items