Limaprost - CAS 74397-12-9
Catalog number: 74397-12-9
Category: Inhibitor
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Molecular Formula:
C22H36O5
Molecular Weight:
380.52
COA:
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Targets:
Others
Description:
Limaprost is a potent platelet adhesion inhibitor and vasodilator that increases blood flow and inhibits platelet aggregation. It is an analog of prostaglandin E1 with structural modifications intended to give a prolonged half-life and greater potency.
Purity:
>98%
Synonyms:
ONO 1206; ONO 1206; ONO 1206; OP 1206; Limaprost; 17α,20-dimethyl-Δ2-PGE1; 17α,20-dimethyl-Δ2-Prostaglandin E1.
MSDS:
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InChIKey:
OJZYRQPMEIEQFC-UAWLTFRCSA-N
InChI:
InChI=1S/C22H36O5/c1-3-4-9-16(2)14-17(23)12-13-19-18(20(24)15-21(19)25)10-7-5-6-8-11-22(26)27/h8,11-13,16-19,21,23,25H,3-7,9-10,14-15H2,1-2H3,(H,26,27)/b11-8+,13-12+/t16-,17+,18+,19+,21+/m0/s1
Canonical SMILES:
CCCCC(C)CC(C=CC1C(CC(=O)C1CCCCC=CC(=O)O)O)O
1.[A memoir of my research on pain and analgesia for 39 years].
Kuraishi Y1. Yakugaku Zasshi. 2014;134(11):1125-42.
This review describes my research for the past 39 years regarding the pharmacology of pain and analgesia. We have demonstrated that the descending noradrenergic system is involved in the analgesic effect of morphine injected into the nucleus reticularis gigantocellularis, and that noradrenaline exerts antinociception mediated by α-adrenoceptors. We have found that noxious mechanical and thermal stimuli to the skin increase the release of substance P and somatostatin, respectively, from the dorsal horn in situ, and that noradrenaline inhibits the release of substance P and glutamate from primary afferents. We developed an animal model of cancer pain using melanoma cells. We have shown that the suppression of cancer pain results in the inhibition of tumor growth and lung metastasis, and that melanoma cells release several algogenic substances including ATP, endothelin-1, and bradykinin. We investigated neuropathic allodynia induced by the chemotherapeutic drugs paciltaxel, oxaliplatin, vincristine, and bortezomib.
2.Comparative study of the efficacy of limaprost and pregabalin as single agents and in combination for the treatment of lumbar spinal stenosis: a prospective, double blind, randomized controlled non-
Kim HJ1, Kim JH2, Park YS3, Suk KS4, Lee JH5, Park MS6, Moon SH7. Spine J. 2016 Mar 29. pii: S1529-9430(16)00439-3. doi: 10.1016/j.spinee.2016.02.049. [Epub ahead of print]
BACKGROUND CONTEXT: Although the simultaneous management of neuronal ischemia-related pain and compression-demyelination-related neuropathic pain is considered optimal while treating lumbar spinal stenosis (LSS), the effect of combination therapy with pregabalin and limaprost has not been elucidated.
3.The NMatrix, a new method of presenting statistics, displays the characteristics of medicines with similar effects used in the treatment of lumbar spinal stenosis concisely and clearly, facilitating the selection of appropriate medications.
Nakamura M1. J Orthop Sci. 2015 Jul;20(4):601-8. doi: 10.1007/s00776-015-0716-6. Epub 2015 Apr 10.
BACKGROUND: It is often difficult to compare the characteristics of a medicine with those of others based on common standards, whereas the application of rational standards would be expected to facilitate the comparison of medicines with similar effects. The present study was conducted to clarify the characteristics of individual medicines and to examine whether rational standards allow the most appropriate medicines to be chosen.
4.Single- and multiple-dose pharmacokinetics and tolerability of limaprost in healthy Chinese subjects.
Chen H1, Zhang Q, Li X, Zhang H, Sun Y, Yin L, Liu C, Cao Y, Gu J, Ding Y. Clin Drug Investig. 2015 Mar;35(3):151-7. doi: 10.1007/s40261-014-0265-3.
BACKGROUND AND OBJECTIVES: Limaprost, a prostaglandin E1 analogue, is used to treat various symptoms in patients with ischemic diseases. The present study was designed to determine the pharmacokinetics and tolerability of single and multiple oral doses of limaprost 5 μg tablets in healthy Chinese subjects.
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CAS 74397-12-9 Limaprost

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