Ligustrazine Hydrochloride - CAS 76494-51-4
Catalog number: 76494-51-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Ligustrazine Hydrochloride is a natural product extracted from the rhizomes of Ligusticum chuanxiong Hort. It displayed a protection effect on injured ECV304 cells in vitro. It also has certain protection effect on the vascular endothelium undergoing CPB, and lower excessive activation of coagulation reaction and inflammation reaction in patients undergoing CPB.
Publictions citing BOC Sciences Products
  • >> More
Solid powder
2,3,5,6-Tetramethylpyrazine hydrochloride;Chuanxiongzine Hydrochlorid;Tetramethylpyrazine hydrochloride;Ligustrazine HCl
10 mM in DMSO
-20°C Freezer
Ligustrazine Hydrochloride displayed a protection effect on injured ECV304 cells in vitro. It also has certain protection effect on the vascular endothelium undergoing CPB, and lower excessive activation of coagulation reaction and inflammation reaction in patients undergoing CPB.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Grams to Kilograms
Boiling Point:
Canonical SMILES:
1.[Preparation and in vitro permeation of tetramethylpyrazine hydrochloride transdermal gel].
Tang Z1, Xu HY, Wang Q. Zhongguo Zhong Yao Za Zhi. 2013 Jul;38(13):2101-4.
The purpose of this study was to prepare tetramethylpyrazine hydrochloride transdermal gel and to study its permeation ability in vitro. The skin permeation ability was evaluated by Valian-Chien permeation cells with isolated rat skin. The concentration of tetramethylpyrazine in samples was determined by HPLC. The optimal formulation was composed with 5% azone, 5% peppermint oil, 8% sodium carboxymethylcellulose and 8% tetramethylpyrazine hydrochloride. The accumulative permeation amount of the gel was (6 731.87 +/- 102.31) microg x cm(-2) in 12 h,and the permeation rate was (535.02 +/- 33.89) microg x cm(-2) x h(-1). The release profile in vitro was in line with zero-order formulation. Tetramethylpyrazine hydrochloride gel prepared in the study would be developed as a novel transdermal preparation.
2.Tetramethylpyrazine-mediated suppression of C6 gliomas involves inhibition of chemokine receptor CXCR4 expression.
Yu K1, Chen Z, Pan X, Yang Y, Tian S, Zhang J, Ge J, Ambati B, Zhuang J. Oncol Rep. 2012 Sep;28(3):955-60. doi: 10.3892/or.2012.1866. Epub 2012 Jun 14.
Tetramethylpyrazine (TMP) is the major component extracted from the Chinese herb Chuanxiong. Increasing numbers of studies have indicated that tetramethylpyrazine hydrochloride (TMPH) has anticancer effects. However, the molecular mechanisms underlying the actions of TMPH have not been fully elucidated. In this study, using real-time RT-PCR and western blot techniques, we demonstrate that TMPH significantly downregulates the expression of the chemokine receptor CXCR4 in C6 glioma cells. Consistent with a role for CXCR4 in cancer development, TMPH inhibits the migration, proliferation and colony formation of C6 glioma cells in vitro more effectively than the CXCR4 antagonist AMD3100. Interestingly, TMPH does not affect the cell cycle when the cells are grown to 50-80% confluency but induces S-phase arrest at 100% confluency, as indicated by a significant reduction in the G1 and G2 populations.
3.Brain microdialysate, CSF and plasma pharmacokinetics of ligustrazine hydrochloride in rats after intranasal and intravenous administration.
Wang Q1, Tang Z, Zhang W. Biopharm Drug Dispos. 2013 Oct;34(7):417-22. doi: 10.1002/bdd.1854. Epub 2013 Aug 14.
The aim of this work was to investigate the pharmacokinetics of ligustrazine hydrochloride (LZH) in plasma, cerebrospinal fluid (CSF) and cerebral cortex after intranasal (10 mg/kg) or intravenous administration (10 mg/kg) in male Sprague-Dawley rats. Plasma, CSF and cerebral cortex microdialysates were collected at timed intervals for the measurement of LZH by a quick and sensitive HPLC-UV method. LZH entered the brain quickly following both routes of administration. No significant difference was observed between the AUCCSF or cortex /AUCplasma ratio of LZH after intranasal administration (38.4%, 17.4%) and that after intravenous injection (45.9%, 19.9%). The drug targeting index (DTI) was 0.85 and 0.91 in the CSF and cortex, respectively. In conclusion, LZH is rapidly absorbed into the systemic circulation following intranasal administration. There is no direct pathway for LZH transport from the nasal cavity to the brain. The rapidity and magnitude of LZH penetration into the brain indicate that intranasal administration of this agent is a promising alternative to intravenous administration.
4.[Protective effect of ligustrazine hydrochloride on homocysteine-injured ECV304 cells].
Xu D1, Wu D. Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1836-9.
OBJECTIVE: To detect the protective effect of ligustrazine hydrochloride on homocysteine-injured ECV304 cells.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products

CAS 27975-19-5 Isosteviol

(CAS: 27975-19-5)

A tetracyclic diterpenoid with a beyerane core has drawn attention because it can exhibit antihypertensive activity, reduce blood glucose, suppress cancer cells...

(CAS: 473545-11-8)

UNIL088 is a water-soluble prodrug of cyclosporine A (CsA), can be rapidly hydrolysed under physiological conditions, and can retain a long shelf-life in aqueou...

(CAS: 1857417-10-7)

MI-538, a 4-methylpyrazole compound, is a double substituted analogue with methylpyrazole at R1 and hydroxyl at R4. MI-538, a potent and selective MLL (Mixed Li...

(CAS: 1700693-96-4)

ARN-5187, a piperazin derivative, has been found to be a REV-ERBβ inhibitor that could induce apoptotic in cancer cells and probably be more effective in breast...

CAS 59-30-3 Folic acid

Folic acid
(CAS: 59-30-3)

Folic acid is a vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, and it also acts as a cofactor in biological reactions involving folate....

CAS 13189-98-5 Fudosteine

(CAS: 13189-98-5)

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.

CAS 118525-35-2 Sagittatoside A

Sagittatoside A
(CAS: 118525-35-2)

Sagittatoside A is a natural compound isolated from traditional Chinese herb Yinyanghuo.

CAS 444932-31-4 TC-O9311

(CAS: 444932-31-4)

TC-O9311 is a potent, selective agonist of GPR139 (EC50 = 39 nM in CHO-K1 cells expressing human GPR139) with no activity against a range of 90 diverse targets.

CAS 105184-37-0 Splenopentin diacetate

Splenopentin diacetate
(CAS: 105184-37-0)

Splenopentin diacetate is a synthetic immunomodulating peptide corresponding to the region 32-34 of a splenic product called splenin (SP) and the thymic hormone...

CAS 141433-60-5 Berberine chloride hydrate

Berberine chloride hydrate
(CAS: 141433-60-5)

The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways ...

CAS 486-28-2 Fraxinol

(CAS: 486-28-2)

Fraxinol can be extracted from the bark of Fraxinus chinensis Roxb.

CAS 41498-37-7 GS 389

GS 389
(CAS: 41498-37-7)

GS 389 is a novel tetrahydroisoquinoline analog which significantly increased cGMP levels in the rat aorta and inhibited cGMP phosphodiesterase from the rabbit ...

(CAS: 1610676-27-1)

CFI-401980, a pyrazolotriazin derivative, has been found to be a TTK inhibitor that could exhibit good antiproliferative activity in some human cancer cell line...


Arg-Gly-Asp-Cys is the binding motif of fibronectin to cell adhesion molecules, and surfaces modified with RGDC were shown to be effective for osteoblast bindin...

CAS 9002-96-4 Tocofersolan

(CAS: 9002-96-4)

Tocofersolan is a synthetic water-soluble version of vitamin E unlike its natural counterpart which are fat soluble . It is polyethylene glycol derivative of α-...

CAS 152751-57-0 Sevelamer HCl

Sevelamer HCl
(CAS: 152751-57-0)

Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

CAS 1453097-13-6 HUHS015

(CAS: 1453097-13-6)

HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. As expect...

CAS 1707147-26-9 THK5351

(CAS: 1707147-26-9)

THK5351 can be radiolabeled and used as a radiotracer for in vivo imaging of tau pathology in the brain. THK5351 bound to AD hippocampal homogenates with high a...

CAS 37640-71-4 Aprindine

(CAS: 37640-71-4)

Aprindine is a Class 1b antiarrhythmic agent as a cardiac depressant used in arrhythmias.

CAS 29908-03-0 Ademetionine

(CAS: 29908-03-0)

S-adenosyl-l-methionine (SAMe) is a naturally-occurring substance which is a major source of methyl groups in the brain. The efficacy of SAMe in treating depres...

Chemical Structure

CAS 76494-51-4 Ligustrazine Hydrochloride

Quick Inquiry

Verification code

Featured Items