|Description||Lificiguat, also known as YC-1, is a inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). YC-1 is widely used as a potent inhibitor of HIF-1alpha both in vitro and in vivo, and is also being developed as a novel anticancer drug. YC-1 effectively inhibits tumor invasion and metastasis, and imply that YC-1 is worth while to further develop as a multipurpose anticancer drug.|
|Appearance||white solid powder|
|Synonyms||YC-1; YC 1; YC1.|
A-92 inhibits the stress response of general control nonderepressible 2 kinase (GCN2 or EIF2AK4) (IC50 value of <0.3 μM). It is potentially used as a chemothera...
Marinopyrrole A is a small molecule Mcl-1 inhibitor. It could induce Mcl-1 proteasomal degradation without transcriptional downregulation. It has the potential ...
KLS-13019, an azetidine derivative, could be a neuroprotective agent and has been found to exbihit much more effective than cannabidiol.
Myoseverin is a microtuble-binding molecule and reversible inhibitor of tubulin polymerization. It binds to tublin leading to myotube fission. Myoseverin affect...
Navamepent is an inflammation mediator inhibitor and lipid modulator originated by Resolvyx Pharmaceuticals and licensed to Auven Therapeutics in 2011. Treatmen...
UNIL088 is a water-soluble prodrug of cyclosporine A (CsA), can be rapidly hydrolysed under physiological conditions, and can retain a long shelf-life in aqueou...
YE 120 is a GPR35 agonist (EC50 = 32 nM in DMR assays), and also displays partial agonist activity in a β-arrestin translocation assay (EC50 = 10.2 μM).
FR-78844 is used as a bone resorption antagonist.
Bropirimine is an immunostimulant as well as anticancer agent and has been found to exhibit direct antitumor activity.
Pep 2-8 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor.
Interferes with TLR4, TLR2/6 signaling; Orally active immunomodulatory agent; Inhibits TNF-α secretion via interference of macrophage TLR4 and TLR 2/6 signaling...
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases.
Butylparaben is used as an antimicrobial preservative in cosmetics. It is also used in medication suspensions and used as a flavoring additive in food.
NSC-601980 analog is the analog of the NSC601980, which shows antitumor activity in the yeast screening experiment.
GYKI-16638 is a novel antiarrhythmic agent, shows combined Class IB and Class III antiarrhythmic properties, resembling the electrophysiological manifestation s...
ML 154 is a neuropeptide S receptor antagonist. It has the potential to be used in the treatment of sleep, anxiety and addiction disorders.
P005672 HCl is a novel, tetracycline-substituted, narrow-spectrum antibiotic compound used for treatment of bacterial infections and neoplasms. It is developed ...
Famprofazone, known to metabolize to Methamphetamine and Amphetamine, is a non-steroidal anti-inflammatory agent (NSAID).
D-Pantothenic acid, also called vitamin B5, is a water-soluble vitamin and an essential nutrient for many animals.
AP-24600 is a bio-active chemical, but no detailed information has been published yet.