Lidocaine hydrochloride monohydrate - CAS 6108-05-0
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Sodium Channel
Lidocaine hydrochloride monohydrate is the hydrochloride monohydrate form of lidocaine, which is an aminoethylamide and a prototypical member of the amide class anesthetics. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. It has properties as a class IB antiarrhythmic, a long-acting membrane stabilizing agent used against ventricular arrhythmia. It interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. It works by blocking sodium channels and thus decreasing the rate of contractions of the heart. It can cause low blood pressure and an irregular heart rate.
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White solid
2’,6’-Acetoxylidide,2-(diethylamino)-,hydrochloride,hydrate;Acetamide,2-(diethylamino)-n-(2,6-dimethylphenyl)-,monohydrochloride;2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate;Lidocaine Hydrochloride;Xyloneural
H2O: soluble
-20°C Freezer
Lidocaine hydrochloride monohydrate is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. It can cause low blood pressure and an irregular heart rate.
Quality Standard:
CP standard
Kilograms to Tons
Boiling Point:
350.8ºC at 760 mmHg
Melting Point:
Canonical SMILES:
1.Comparative Evaluation of Mental Incisal Nerve Block, Inferior Alveolar Nerve Block, and Their Combination on the Anesthetic Success Rate in Symptomatic Mandibular Premolars: A Randomized Double-blind Clinical Trial.
Aggarwal V1, Singla M2, Miglani S3, Kohli S3. J Endod. 2016 Apr 14. pii: S0099-2399(16)30024-3. doi: 10.1016/j.joen.2016.02.015. [Epub ahead of print]
INTRODUCTION: The purpose of this study was to compare the effectiveness of mental incisive nerve block (MINB) and inferior alveolar nerve block (IANB) that were given alone or in combination to provide anesthesia to symptomatic mandibular premolars.
2.Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.
Qiu XS1, Chauveau S1, Anyukhovsky EP1, Rahim T1, Jiang YP1, Harleton E1, Feinmark SJ1, Lin RZ1, Coronel R1, Janse MJ1, Opthof T1, Rosen TS1, Cohen IS2, Rosen MR1. Circ Arrhythm Electrophysiol. 2016 Apr;9(4). pii: e003655. doi: 10.1161/CIRCEP.115.003655.
BACKGROUND: Drugs are screened for delayed rectifier potassium current (IKr) blockade to predict long QT syndrome prolongation and arrhythmogenesis. However, single-cell studies have shown that chronic (hours) exposure to some IKr blockers (eg, dofetilide) prolongs repolarization additionally by increasing late sodium current (INa-L) via inhibition of phosphoinositide 3-kinase. We hypothesized that chronic dofetilide administration to intact dogs prolongs repolarization by blocking IKr and increasing INa-L.
3.Simultaneous Treatment with Subcutaneous Injection of Golimumab and Intra-articular Injection of Triamcinolone Acetonide (K-Method) in Patients with Rheumatoid Arthritis Undergoing Switching of Biologics: Retrospective Case-Control Study.
Kanbe K1, Chiba J1, Inoue Y1, Taguchi M1, Yabuki A1, Deguchi T1. Clin Med Insights Arthritis Musculoskelet Disord. 2016 Apr 4;9:45-9. doi: 10.4137/CMAMD.S38442. eCollection 2016.
BACKGROUND: Tight control of severe rheumatoid arthritis (RA) in patients with high disease activity, even when using biologics, is sometimes difficult using a treat-to-target strategy. Switching from one biologic to another is associated with lower efficacy than that in treatment-naive cases. We developed the K-method that involves simultaneous treatment with golimumab and intra-articular joint injection of triamcinolone acetonide (TA) in patients undergoing switching of biologics. We performed this retrospective case-control study to investigate the efficacy of achieving an immediate treatment response using the K-method.
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CAS 6108-05-0 Lidocaine hydrochloride monohydrate

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