Lidocaine hydrochloride - CAS 73-78-9
Catalog number:
73-78-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C14H23ClN2O
Molecular Weight:
270.8
COA:
Inquire
Targets:
Others
Description:
Lidocaine hydrochloride is the first amino amide–type local anesthetic and antiarrhythmic drug, which has anti-inflammatory properties in vitro and in vivo. It was first synthesized under the name xylocaine by Swedish chemist Nils Lofgren in 1943. It is approximately 95% metabolized (dealkylated) in the liver by CYP3A4 to the pharmacologically-active metabolites monoethylglycinexylidide and then subsequently to the inactive glycine xylidide. It is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.
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Purity:
98%
Appearance:
White powder
Synonyms:
Alpha-(diethylamino)-2',6'-acetoxylidide hydrochloride;2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamidmonohydrochloride;Lignocaine hydrochloride;Xylocaine hydrochloride
Solubility:
H2O: > 36 mg/mL
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Lidocaine hydrochloride is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.
Quality Standard:
USP/BP
Shelf Life:
2 month in rt, long time
Quantity:
Kilogram to ton
Boiling Point:
350.8 °C at 760 mmHg
Melting Point:
77-78 °C
Density:
0.6 g/cm3
InChIKey:
IYBQHJMYDGVZRY-UHFFFAOYSA-N
InChI:
InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H
Canonical SMILES:
CCN(CC)CC(=O)NC1=C(C=CC=C1C)C.Cl
1.Prolonged Drainage and Intrapericardial Bleomycin Administration for Cardiac Tamponade Secondary to Cancer-Related Pericardial Effusion.
Numico G1, Cristofano A, Occelli M, Sicuro M, Mozzicafreddo A, Fea E, Colantonio I, Merlano M, Piovano P, Silvestris N. Medicine (Baltimore). 2016 Apr;95(15):e3273. doi: 10.1097/MD.0000000000003273.
Malignant pericardial effusion (MPE) is a serious complication of several cancers. The most commonly involved solid tumors are lung and breast cancer. MPE can give rise to the clinical picture of cardiac tamponade, a life threatening condition that needs immediate drainage. While simple pericardiocentesis allows resolution of the symptoms, MPE frequently relapses unless further procedures are performed. Prolonged drainage, talcage with antineoplastic agents, or surgical creation of a pleuro-pericardial window are the most commonly suggested ones. They all result in MPE resolution and high rates of long-term control. Patients suitable for further systemic treatments can have a good prognosis irrespective of the pericardial site of disease. We prospectively enrolled patients with cardiac tamponade treated with prolonged drainage associated with Bleomycin administration.Twenty-two consecutive patients with MPE and associated signs of hemodynamical compromise underwent prolonged drainage and subsequent Bleomycin administration.
2.Investigation on Drug Solubility Enhancement Using Deep Eutectic Solvents and Their Derivatives.
Li Z1, Lee PI2. Int J Pharm. 2016 Apr 11. pii: S0378-5173(16)30301-5. doi: 10.1016/j.ijpharm.2016.04.018. [Epub ahead of print]
Deep eutectic solvent (DES) is a room temperature liquid typically formed by mixing two solid compounds, such as a quaternary ammonium salt (QAS) (e.g. choline chloride) and a hydrogen bond donor (HBD) (e.g. urea or a carboxylic acid) at their eutectic composition. Very often, a range of room temperature liquids can also be obtained near the eutectic composition. Hence, it is more convenient to introduce a more general term deep eutectic solvent derivatives (DESDs) to describe a wide range of DES-like derivatives including those derived from ternary mixtures. The melting point of the mixture is lowered because the hydrogen bonding between DESD components reduces the lattice energy of components of the eutectic system. Based on the analysis of available data for 22 such choline chloride-based DES pairs, we found that the observed melting point depression can be statistically correlated with the difference between the hydrogen bonding contribution (δh) and the polar contribution (δp) to the solubility parameter of the hydrogen bond donor (HBD) component.
3.Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration.
Qiu XS1, Chauveau S1, Anyukhovsky EP1, Rahim T1, Jiang YP1, Harleton E1, Feinmark SJ1, Lin RZ1, Coronel R1, Janse MJ1, Opthof T1, Rosen TS1, Cohen IS2, Rosen MR1. Circ Arrhythm Electrophysiol. 2016 Apr;9(4). pii: e003655. doi: 10.1161/CIRCEP.115.003655.
BACKGROUND: Drugs are screened for delayed rectifier potassium current (IKr) blockade to predict long QT syndrome prolongation and arrhythmogenesis. However, single-cell studies have shown that chronic (hours) exposure to some IKr blockers (eg, dofetilide) prolongs repolarization additionally by increasing late sodium current (INa-L) via inhibition of phosphoinositide 3-kinase. We hypothesized that chronic dofetilide administration to intact dogs prolongs repolarization by blocking IKr and increasing INa-L.
4.Acute physiological responses to castration-related pain in piglets: the effect of two local anesthetics with or without meloxicam.
Bonastre C1, Mitjana O1, Tejedor MT2, Calavia M3, Yuste AG3, Úbeda JL3, Falceto MV1. Animal. 2016 Apr 15:1-8. [Epub ahead of print]
Methods to reduce castration-related pain in piglets are still issues of concern and interest for authorities and producers. Our objectives were to estimate the effectiveness of two protocols of local anesthesia (lidocaine and the combination of lidocaine+bupivacaine) as well as the use of meloxicam as a postoperative analgesic in alleviating castration-related pain, measured by acute physiological responses. Eight groups (15 piglets/group) were included in the study: (1) castration without anesthesia or analgesia, without meloxicam (TRAD WITHOUT), (2) castration without anesthesia or analgesia, but with meloxicam (TRAD WITH), (3) handling without meloxicam (SHAM WITHOUT), (4) handling with meloxicam (SHAM WITH), (5) castration after local anesthesia with lidocaine but without meloxicam (LIDO WITHOUT), (6) castration after local anesthesia with lidocaine and meloxicam (LIDO WITH), (7) castration after local anesthesia with lidocaine+bupivacaine without meloxicam (LIDO+BUPI WITHOUT), (8) castration after local anesthesia with lidocaine+bupivacaine and meloxicam (LIDO+BUPI WITH).
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CAS 73-78-9 Lidocaine hydrochloride

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