Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra (liquorice) or Glycyrrhiza inflata. It is a potent membrane-active agent that transforms normal erythrocytes into echinocytes. It exhibits potent antimalarial activity and might be developed into a new antimalarial drug. It had anti-tumor activity in all cell lines tested and enhanced the effect of paclitaxel and vinblastine chemotherapy.