|Targets||Aromatase | Cytochrome P450|
|Description||This active molecular has a potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits P450-dependent ATRA-4-hydroxylase to an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. Meanwhile, liarozole also inhibits aromatase that catalyzes estrogen biosynthesis in rating-limited step. In Aug 2005, clinical development was ongoing for Ichthyosis in Europe.In Jan 2006, Phase-II/III clinical trials in Ichthyosis was ongoing in Europe and in Canada.|
|Synonyms||6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole, R 75251; R-75251; R75251|
|Solubility||Soluble in DMSO|
|Application||treatment for Ichthyosis|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator:Janssen Pharmaceutica|
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