|Description||LH846 is a selective inhibitor of CK1δ, which displays no inhibitory activity at CK2. It inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein, showing to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.|
D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).
PF-670462 is a potent and selective inhibitor of CK1ε in isolated enzyme preparations. It inhibits PER protein nuclear translocation causing phase shifts in cir...
LH846 is a selective inhibitor of CK1δ, which displays no inhibitory activity at CK2. It inhibits CK1δ-dependent phosphorylation and degradation of PER1 protei...
PF 5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε) (IC50 values are 3.9 and 17 nM, respectively). It mediates circadian rhyt...
The hydrochloride salt form of (R)-DRF053, which is a cdk/CK1 inhibitor and could be used in studies in the cancer treatment with combinations of CDK kinase and...
PF 4800567 hydrochloride
PF 4800567 is a casein kinase 1e (CK1e) selective inhibitor that is 22 fold selective for the CK1e isoform over CK1d (IC50= 32 and 711 nM for CK1ε and CK1δ resp...
CKI 7 dihydrochloride
The hydrochloride salt form of CKI 7, which has been found to be a CK1 inhibitor.
IC261, also known as SU5607, is a potent and selective CK1 inhibitor. IC261 triggers the mitotic checkpoint and induces p53-dependent postmitotic effects.
SR-3029, a small molecule inhibitor that targets specificly CK1δ/CK1ε, was effective at reducing the growth of breast cancer in multiple mouse models without an...