|Description||LGK974 is a selective and orally bioavailable Porcupine inhibitor under development for the treatment of cancers that are driven by the Wnt pathway in a Wnt ligand-dependent manner. A Phase I study of LGK974 in patients with melanoma or lobular breast cancer is currently ongoing.|
|Appearance||white solid powder|
|Synonyms||LGK-974; LGK974; LGK 974.|
LGK974 is a selective and orally bioavailable Porcupine inhibitor under development for the treatment of cancers that are driven by the Wnt pathway in a Wnt lig...
Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
GNF1331 is a potent, selective and orally bioavailable porcupine (PORCN) inhibitor with IC50 value of 12 nM. It plays a critical role in multiple cancers, such ...
IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.