LGB-321 HCl - CAS 1210416-93-5
Catalog number:
1210416-93-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C23H24Cl2F3N5O2
Molecular Weight:
530.37
COA:
Inquire
Targets:
Pim
Description:
This active molecular is a selective ATP-competitive inhibitor of Pan-PIM kinase. LGB-321 is active in PIM2 dependent cell lines that is quite different to other PIM inhibitors reported before. LGB321 inhibits proliferation of a number of cell lines derived from diverse hematological malignancies which is consistent with its activity on all three PIM kinases. LGB321 is efficient in inhibiting tumor xenografts and is well-tolerated within the therapeutic exposure range in animal models.
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Purity:
98%
Appearance:
Powder
Synonyms:
N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide dihydrochloride
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
anti-tumor
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Canonical SMILES:
O=C(NC1=C(N2C[C@@H](N)[C@H](O)[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3.[H]Cl.[H]Cl
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