|Description||KH1060 metabolism could be blocked by the cytochrome P450 inhibitor, ketoconazole. KH1060 was not an effective competitor of C24 oxidation of 1alpha,25-(OH)2D3. Certain hydroxylated metabolites of KH1060 retained significant biological activity in vitamin D-dependent reporter gene systems (chloramphenicol acetyltransferase). KH 1060 inhibited PBMC proliferation and decreased TNF-alpha levels in IBD patients and this effect was synergistic with anti-TNF-alpha. VDR protein levels were significantly increased by PBMC treatment with KH 1060 or anti-TNF-alpha or their combination in ulcerative colitis (UC) patients, and decreased in Crohn's disease (CD) patients, treating the cells with KH 1060. A synergistic inhibition was registered combining KH 1060 and anti-TNF, at well-defined concentrations. 0.1 nM KH 1060 produced a significant decrease in TNF-alpha levels, determined by ELISA, although less remarkable than in the presence of anti-TNF.|
|Synonyms||KH 106; KH 1060; KH-1060; KH1060|
Calcitetrol is the hormonally active form of vitamin D with three hydroxyl groups. It increases blood calcium levels ([Ca2+]) by promoting absorption of dietary...
LG190155 is a moderately potent VDR agonist.
24, 25-Dihydroxy VD2
24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2, which is a synthetic analog of Vitamin D.
Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification. lt mediates calcium and phosphorus homeo...
Synthetic analog of vitamin D. Antihyperparathyroid.
(24S)-24,25-Dihydroxycholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs.
1alpha-Hydroxy VD4 , a 1alpha(OH)D derivative, can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU and P31/FUJ cells.
Impurity B of Calcitriol
Impurity B of Calcitriol is the hormonally active form of vitamin D, and Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor...
1α, 24, 25-Trihydroxy VD2
1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog.
(24S)-MC 976 is a Vitamin D3 derivative.
Calcitriol Impurities D
One of the impurities of Calcitriol, an active metabolite of VD3, could be a agonist of vitamin D receptor.
Maxacalcitol is non-calcemic vitamin D3 analog and ligand of VDR-like receptors.
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(24R)-MC 976 is a Vitamin D3 derivative.
Α hydroxylated metabolite of Vitamin D3
Vitamin D3 analog.
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Calcitriol is the hormonally active form of vitamin D.