Levoprotiline hydrochloride - CAS 76496-69-0
Catalog number: 76496-69-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C20H24ClNO
Molecular Weight:
329.87
COA:
Inquire
Targets:
Histamine Receptor
Description:
Levoprotiline is a Histamine H1 receptor antagonist originated by Novartis. It is an antidepressant. But clinical trials for Major depressive disorder were discontinued.
Purity:
98%
Appearance:
Powder
Synonyms:
Levoprotiline hydrochloride; Levoprotiline HCl; CGP 12103 A; CGP-12 103 A; CGP 12103; CGP 12103A; CGS 12103;(R)-alpha-((methylamino)methyl)-9,10-Ethanoanthracene-9(10H)-ethanol bydrochloride
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
Inquire
Application:
Major depressive disorder
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
MUOSVLIKDZRWMP-DQBGKMJDSA-N
InChI:
1S/C20H23NO.ClH/c1-21-13-14(22)12-20-11-10-15(16-6-2-4-8-18(16)20)17-7-3-5-9-19(17)20;/h2-9,14-15,21-22H,10-13H2,1H3;1H/t14-,15?,20?;/m1./s1
Canonical SMILES:
CNC[C@@H](CC12CCC(c3c1cccc3)c4c2cccc4)O.Cl
Current Developer:
Originator Novartis
1.Pharmacological profile of the new antidepressant levoprotiline.
Noguchi S;Okada M;Inukai T Arzneimittelforschung. 1992 Jun;42(6):787-94.
The pharmacological properties of a new antidepressant, levoprotiline ((-)-R-a-[(methylamino)methyl]-9,10-ethanoanthracene-9(10H)- ethanol hydrochloride, CGP 12103 A, CAS 76496-69-0) were investigated. 1. Central nervous system: Levoprotiline did not have any marked effects on the general behaviour of mice and rats at low doses, however it slightly suppressed the righting reflex and spontaneous motor activity of mice at higher doses. In rats, chewing behaviour and salivation were observed at higher doses. Levoprotiline had no effects on the traction test (mice) and inclined screen test (rats). Levoprotiline induced a slight drowsy EEG pattern, the effect being similar to that of typical antidepressants such as maprotiline or imipramine but the degree of potency of levoprotiline was less than that of the latter two drugs. Levoprotiline and maprotiline did not inhibit the arousal response induced by physostigmine, while imipramine clearly suppressed the response. 2. Respiratory and cardiovascular system: Heart rate decrease and QT prolongation were observed in anesthetized dogs. In an in vitro study, levoprotiline caused only slight stimulation of noradrenaline transmission in the isolated guinea pig atrium.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products


CAS 2438-32-6 Dexchlorpheniramine maleate

Dexchlorpheniramine maleate
(CAS: 2438-32-6)

Dexchlorpheniramine maleate, also known as Polaramine, is an antihistamine to treat allergic conditions, urticaria and allergic conjunctivitis and pruritus.

CAS 149629-70-9 Impentamine dihydrobromide

Impentamine dihydrobromide
(CAS: 149629-70-9)

Impentamine dihydrobromide is the dihydrobromide salt of impentamine, which is a highly selective and the most potent histamine H3 antagonist with pA2 value of ...

CAS 1103522-80-0 Bavisant dihydrochloride hydrate

Bavisant dihydrochloride hydrate
(CAS: 1103522-80-0)

The dihydrochloride hydrate salt form of Bavisant which is an orally bioavaliable and selective H3 receptor antagonist that could probably useful in the treatme...

CAS 100130-32-3 VUF 8430 dihydrobromide

VUF 8430 dihydrobromide
(CAS: 100130-32-3)

VUF 8430 dihydrobromide is a high affinity (pKi = 7.5) and potent histamine H4 receptor full agonist (pEC50 = 7.3). VUF 8430 also has moderate affinity for H3 r...

CAS 108612-45-9 Mizolastine

Mizolastine
(CAS: 108612-45-9)

Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic r...

CAS 459168-41-3 JNJ-7777120

JNJ-7777120
(CAS: 459168-41-3)

JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other h...

CAS 550-70-9 trans-Triprolidine hydrochloride

trans-Triprolidine hydrochloride
(CAS: 550-70-9)

Trans-Triprolidine hydrochloride is a potent histamine H1 receptor antagonist with anticholinergic properties. Triprolidine is used for the treatment and preven...

CAS 7456-24-8 Fonazine

Fonazine
(CAS: 7456-24-8)

Dimetotiazine is a histamine H1 receptor antagonist. It is a phenothiazine drug used for the treatment of migraine.

Chemical Structure

CAS 76496-69-0 Levoprotiline hydrochloride

Quick Inquiry

Verification code

Featured Items