Levoprotiline hydrochloride - CAS 76496-69-0
Catalog number: 76496-69-0
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Histamine Receptor
Levoprotiline is a Histamine H1 receptor antagonist originated by Novartis. It is an antidepressant. But clinical trials for Major depressive disorder were discontinued.
Levoprotiline hydrochloride; Levoprotiline HCl; CGP 12103 A; CGP-12 103 A; CGP 12103; CGP 12103A; CGS 12103;(R)-alpha-((methylamino)methyl)-9,10-Ethanoanthracene-9(10H)-ethanol bydrochloride
Soluble in DMSO
-20℃ Freezer
Major depressive disorder
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Canonical SMILES:
Current Developer:
Originator Novartis
1.Pharmacological profile of the new antidepressant levoprotiline.
Noguchi S;Okada M;Inukai T Arzneimittelforschung. 1992 Jun;42(6):787-94.
The pharmacological properties of a new antidepressant, levoprotiline ((-)-R-a-[(methylamino)methyl]-9,10-ethanoanthracene-9(10H)- ethanol hydrochloride, CGP 12103 A, CAS 76496-69-0) were investigated. 1. Central nervous system: Levoprotiline did not have any marked effects on the general behaviour of mice and rats at low doses, however it slightly suppressed the righting reflex and spontaneous motor activity of mice at higher doses. In rats, chewing behaviour and salivation were observed at higher doses. Levoprotiline had no effects on the traction test (mice) and inclined screen test (rats). Levoprotiline induced a slight drowsy EEG pattern, the effect being similar to that of typical antidepressants such as maprotiline or imipramine but the degree of potency of levoprotiline was less than that of the latter two drugs. Levoprotiline and maprotiline did not inhibit the arousal response induced by physostigmine, while imipramine clearly suppressed the response. 2. Respiratory and cardiovascular system: Heart rate decrease and QT prolongation were observed in anesthetized dogs. In an in vitro study, levoprotiline caused only slight stimulation of noradrenaline transmission in the isolated guinea pig atrium.
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CAS 76496-69-0 Levoprotiline hydrochloride

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