Levofloxacin - CAS 100986-85-4
Catalog number: 100986-85-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H20FN3O4
Molecular Weight:
361.37
COA:
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Targets:
Antibacterial
Description:
Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin.
Purity:
>98%
Synonyms:
Fluoroquinolone
MSDS:
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InChIKey:
GSDSWSVVBLHKDQ-JTQLQIEISA-N
InChI:
InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1
Canonical SMILES:
CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
1.Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?
Bidell MR1, Lodise TP1. Pharmacotherapy. 2016 May 3. doi: 10.1002/phar.1761. [Epub ahead of print]
Fluoroquinolone antibiotics recently have gained increased national attention due to safety concerns. A well-described and serious adverse event associated with receipt of fluoroquinolones is tendinitis and tendon rupture. These tendon injuries can result in long-term sequelae, including chronic pain and mobility restrictions, and may warrant surgery. Due to the severity of these adverse events, a black box warning is included in the product labeling of all fluoroquinolones. In light of the mounting concerns surrounding fluoroquinolone-associated toxicities, the purpose of this clinical review is to provide a comprehensive summary of the risk of tendinopathy associated with levofloxacin, one of the most widely prescribed antibiotics in the United States, across in vitro, animal, and clinical studies, relative to other antibiotics. As part of this review, clinical presentation and onset, proposed mechanisms, patient-specific risk factors, and management of fluoroquinolone-induced tendon injury are summarized.
2.Impact of a short exposure to levofloxacin on faecal densities and relative abundance of total and quinolone-resistant Enterobacteriaceae.
Bernard J1, Armand-Lefèvre L2, Luce E3, El Mniai A3, Chau F4, Casalino E1, Andremont A2, Ruppé E5. Clin Microbiol Infect. 2016 Apr 25. pii: S1198-743X(16)30091-X. doi: 10.1016/j.cmi.2016.04.015. [Epub ahead of print]
Emergence of resistant Enterobacteriaceae in the intestinal microbiota during antibiotic treatment is well documented but its early dynamic is not. Here, we compared the densities of total Enterobacteriaceae and relative abundance (RA) of quinolone - resistant Enterobacteriaceae (QRE) in the first stool passed by patients who had a short exposure to levofloxacin (levofloxacin, n=12) or not (control, n=8). Mean densities [SD] (log CFU/g stool) of total Enterobacteriaceae were lower in the levofloxacin than in the control group (3.4 [1.6] vs. 6.7 [1.7] respectively, p<0.001). Conversely, mean RA [SD] of QRE was significantly higher in the levofloxacin group than in the control group (49.7% [23.4] vs. 0.1% [3.2] respectively, p<0.05). In conclusion, even a short exposure to levofloxacin has a profound impact on the densities of total Enterobacteriaceae and the QRE-RA.
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CAS 100986-85-4 Levofloxacin

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