Levofloxacin - CAS 100986-85-4
Catalog number:
100986-85-4
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C18H20FN3O4
Molecular Weight:
361.37
COA:
Inquire
Targets:
Antibacterial
Description:
Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Fluoroquinolone
MSDS:
Inquire
1.Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?
Bidell MR1, Lodise TP1. Pharmacotherapy. 2016 May 3. doi: 10.1002/phar.1761. [Epub ahead of print]
Fluoroquinolone antibiotics recently have gained increased national attention due to safety concerns. A well-described and serious adverse event associated with receipt of fluoroquinolones is tendinitis and tendon rupture. These tendon injuries can result in long-term sequelae, including chronic pain and mobility restrictions, and may warrant surgery. Due to the severity of these adverse events, a black box warning is included in the product labeling of all fluoroquinolones. In light of the mounting concerns surrounding fluoroquinolone-associated toxicities, the purpose of this clinical review is to provide a comprehensive summary of the risk of tendinopathy associated with levofloxacin, one of the most widely prescribed antibiotics in the United States, across in vitro, animal, and clinical studies, relative to other antibiotics. As part of this review, clinical presentation and onset, proposed mechanisms, patient-specific risk factors, and management of fluoroquinolone-induced tendon injury are summarized.
2.Impact of a short exposure to levofloxacin on faecal densities and relative abundance of total and quinolone-resistant Enterobacteriaceae.
Bernard J1, Armand-Lefèvre L2, Luce E3, El Mniai A3, Chau F4, Casalino E1, Andremont A2, Ruppé E5. Clin Microbiol Infect. 2016 Apr 25. pii: S1198-743X(16)30091-X. doi: 10.1016/j.cmi.2016.04.015. [Epub ahead of print]
Emergence of resistant Enterobacteriaceae in the intestinal microbiota during antibiotic treatment is well documented but its early dynamic is not. Here, we compared the densities of total Enterobacteriaceae and relative abundance (RA) of quinolone - resistant Enterobacteriaceae (QRE) in the first stool passed by patients who had a short exposure to levofloxacin (levofloxacin, n=12) or not (control, n=8). Mean densities [SD] (log CFU/g stool) of total Enterobacteriaceae were lower in the levofloxacin than in the control group (3.4 [1.6] vs. 6.7 [1.7] respectively, p<0.001). Conversely, mean RA [SD] of QRE was significantly higher in the levofloxacin group than in the control group (49.7% [23.4] vs. 0.1% [3.2] respectively, p<0.05). In conclusion, even a short exposure to levofloxacin has a profound impact on the densities of total Enterobacteriaceae and the QRE-RA.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Antibacterial Products


CAS 1405-89-6 Bacitracin Zinc

Bacitracin Zinc
(CAS: 1405-89-6)

Bacitracin Zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.

CAS 15686-71-2 Cephalexin

Cephalexin
(CAS: 15686-71-2)

Cephalexin increases the activity of superficial mucous cells and orifice mucous cells of gastric glands, and inhibits the activity of cervix mucous cells.

CAS 59-87-0 Nitrofural

Nitrofural
(CAS: 59-87-0)

Nitrofural is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50 = 590 mg/kg)

Ribocil-C
(CAS: 1825355-56-3)

Ribocil-C is a more active analog of ribocil. Ribocil is a potent and highly selective synthetic mimic of FMN and inhibit bacterial growth both in vitro and in ...

CAS 76801-85-9 Azathramycin

Azathramycin
(CAS: 76801-85-9)

Azithromycin, derived from erythromycin, is a antibiotic. It binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. It is an...

CAS 123171-59-5 Cefepime Dihydrochloride Monohydrate

Cefepime Dihydrochloride Monohydrate
(CAS: 123171-59-5)

Cefepime is an extended-spectrum parenteral cephalosporin antibiotic active in vitro against a broad spectrum of gram-positive and gram-negative aerobic bacteri...

CAS 24168-96-5 Isoconazole nitrate

Isoconazole nitrate
(CAS: 24168-96-5)

Isoconazole nitrate (Travogen) is an azole antifungal reagent.Nigerian and British medical researchers found that for foot and vaginal infections, isoconazole h...

CAS 98079-51-7 Lomefloxacin

Lomefloxacin
(CAS: 98079-51-7)

Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms, which is commonly used to ...

CAS 24390-14-5 Doxycycline Hyclate

Doxycycline Hyclate
(CAS: 24390-14-5)

Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections.

CAS 127-69-5 Sulfisoxazole

Sulfisoxazole
(CAS: 127-69-5)

Sulfisoxazole is a sulfonamide antibacterial with an oxazole substituent.

CAS 4146-30-9 Framycetin sulphate

Framycetin sulphate
(CAS: 4146-30-9)

Neomycin is an aminoglycoside antibiotic found in many topical medications such as creams, ointments, and eyedrops. Neomycin belongs to aminoglycoside class of ...

CAS 37321-09-8 Apramycin

Apramycin
(CAS: 37321-09-8)

Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic d...

CAS 68077-27-0 Norfloxacin hydrochloride

Norfloxacin hydrochloride
(CAS: 68077-27-0)

Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA...

CAS 72558-82-8 Ceftazidime

Ceftazidime
(CAS: 72558-82-8)

Ceftazidime is an antibiotic useful for the treatment of a number of bacterial infections. It is a third-generation cephalosporin, but it is not used to treat v...

CAS 17784-12-2 Sulfacytine

Sulfacytine
(CAS: 17784-12-2)

Sulfacytine, a benzenesulfonamide derivative, could be used as an antibiotic through restraining the formation of folate.

CAS 144-74-1 Sulfathiazole sodium

Sulfathiazole sodium
(CAS: 144-74-1)

Sulfathiazole is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in h...

CAS 138199-71-0 Levofloxacin Hemihydrate

Levofloxacin Hemihydrate
(CAS: 138199-71-0)

The hydrate form of Levofloxacin, an Ofloxacin derivative, could be commonly used as an antibacterial agent through influencing DNA replication.

CAS 69-52-3 Ampicillin sodium

Ampicillin sodium
(CAS: 69-52-3)

Ampicillin is a beta-lactam antibiotic that is part of the aminopenicillin family.

CHIR-29498
(CAS: 236102-25-3)

CHIR-29498 is a peptoid antibacterial agent.

Oritavancin diphosphate
(CAS: 192564-14-0)

Oritavancin, also known as LY333328, is a novel semisynthetic glycopeptide antibiotics.Oritavancin possesses potent and rapid bactericidal activity in vitro aga...

Chemical Structure

CAS 100986-85-4 Levofloxacin

Quick Inquiry

Verification code

Featured Items