Levocabastine - CAS 79516-68-0
Catalog number:
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Histamine Receptor
Levocabastine is a selective second-generation Histamine H1 receptor antagonist. It is used for Allergic conjunctivitis and Seasonal allergic rhinitis。Levocabastine is also a potent and selective antagonist for the neurotensin receptor NTS2 and it can be used to characterise the different neurotensin subtypes.
Publictions citing BOC Sciences Products
  • >> More
Levocabastine, Livostin, Bilina;(3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid
Soluble in DMSO
-20℃ Freezer
Allergic conjunctivitis; Seasonal allergic rhinitis
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
1.23 g/cm3
Canonical SMILES:
Current Developer:
Janssen-Cilag; Kyowa Hakko Kirin; Nippon Shinyaku; Santen Pharmaceutical
1.In vitro effects of preserved and unpreserved anti-allergic drugs on human corneal epithelial cells.
Guzman-Aranguez A1, Calvo P, Ropero I, Pintor J. J Ocul Pharmacol Ther. 2014 Nov;30(9):790-8. doi: 10.1089/jop.2014.0030. Epub 2014 Aug 6.
PURPOSE: Treatment with topical eye drops for long-standing ocular diseases like allergy can induce detrimental side effects. The purpose of this study was to investigate in vitro cytotoxicity of commercially preserved and unpreserved anti-allergic eye drops on the viability and barrier function of monolayer and stratified human corneal-limbal epithelial cells.
2.The effect of topical corticosteroids, topical antihistamines, and preservatives on human ciliary beat frequency.
Jiao J1, Meng N, Zhang L. ORL J Otorhinolaryngol Relat Spec. 2014;76(3):127-36. doi: 10.1159/000363575. Epub 2014 Jun 24.
BACKGROUND: The aim of this study was to investigate the effect of the corticosteroids, the antihistamines, and the preservatives benzalkonium chloride (BKC) and potassium sorbate (PS) in intranasal medications on human nasal epithelial ciliary beat frequency (CBF).
3.Once-daily dosing of levocabastine has comparable efficacy to twice-daily dosing in the treatment of allergic rhinitis assessed in an allergen challenge chamber.
Murdoch RD, Bareille P, Ignar D, Mark S, Miller SR, Gupta A, Salapatek AM, Patel P. Int J Clin Pharmacol Ther. 2015 Oct;53(10):811-8. doi: 10.5414/CP202389.
OBJECTIVES: To test the hypothesis that intranasal levocabastine (LEVO) may provide benefits as a oncedaily treatment in allergic rhinitis (AR), this non-inferiority study compared the effect at steady state of once- and twice-daily dosing with LEVO on allergen-induced nasal symptoms in AR patients.
4.Synthesis and binding characteristics of [3H]neuromedin N, a NTS2 receptor ligand.
Tóth F1, Mallareddy JR1, Tourwé D2, Lipkowski AW3, Bujalska-Zadrozny M4, Benyhe S1, Ballet S2, Tóth G1, Kleczkowska P5. Neuropeptides. 2015 Dec 8. pii: S0143-4179(15)00224-3. doi: 10.1016/j.npep.2015.12.004. [Epub ahead of print]
Neurotensin (NT) and its analog neuromedin N (NN) are formed by the processing of a common precursor in mammalian brain tissue and intestines. The biological effects mediated by NT and NN (e.g. analgesia, hypothermia) result from the interaction with G protein-coupled receptors. The goal of this study consisted of the synthesis and radiolabeling of NN, as well as the determination of the binding characteristics of [3H]NN and G protein activation by the cold ligand. In homologous displacement studies a weak affinity was determined for NN, with IC50 values of 454nM in rat brain and 425nM in rat spinal cord membranes. In saturation binding experiments the Kd value proved to be 264.8±30.18nM, while the Bmax value corresponded to 3.8±0.2pmol/mg protein in rat brain membranes. The specific binding of [3H]NN was saturable, interacting with a single set of homogenous binding sites. In sodium sensitivity experiments, a very weak inhibitory effect of Na+ ions was observed on the binding of [3H]NN, resulting in an IC50 of 150.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Histamine Receptor Products

CAS 80012-43-7 Epinastine

(CAS: 80012-43-7)

Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for ...

(CAS: 1152747-82-4)

This active molecular is a histamine H3 receptor antagonist. The IC50 of Enerisant is 4.9 nM in H3 receptor binding assay using (R)-α-methyl[3H]histamine. In th...

CAS 1104-22-9 Meclizine 2HCl

Meclizine 2HCl
(CAS: 1104-22-9)

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation...

CAS 58-73-1 Diphenhydramine

(CAS: 58-73-1)

Diphenhydramine is a histamine H1 antagonist. t competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous hist...

CAS 5636-83-9 Dimethindene

(CAS: 5636-83-9)

Dimethindene is a selective histamine H1 antagonist. It binds to the histamine H1 receptor. It is an antiallergic drug and is used in hypersensitivity reactions...

CAS 59-33-6 Pyrilamine maleate salt

Pyrilamine maleate salt
(CAS: 59-33-6)

Pyrilamine maleate salt is a first generation antihistamine and binds with high affinity to G(q/11) protein. It is commonly utilized as a radioligand binding as...

CAS 7456-24-8 Fonazine

(CAS: 7456-24-8)

Dimetotiazine is a histamine H1 receptor antagonist. It is a phenothiazine drug used for the treatment of migraine.

CAS 76963-41-2 Nizatidine

(CAS: 76963-41-2)

Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM.

CAS 84-96-8 Trimeprazine

(CAS: 84-96-8)

Alimemazine is a phenothiazine derivative as a Histamine Receptor antagonist. It can be used as an antipruritic . It also acts as a sedative, hypnotic, and anti...

CAS 1028327-66-3 VUF10460

(CAS: 1028327-66-3)

VUF10460 is a specific non-imidazole histamine H4 receptor agonist (pKi= 7.46, 8.22 for rat H4 receptor and human H4 receptor respectively) with 50-fold selecti...

Pitolisant oxalate
(CAS: 362665-57-4)

Tiprolisant is potent and selective nonimidazole inverse agonist at the histamine H3 receptor. (Ki=0.16 nM).

CAS 1163-36-6 Clemizole hydrochloride

Clemizole hydrochloride
(CAS: 1163-36-6)

The hydrochloride salt form of Clemizole that has hepatitis C antiviral effect through restraining NS4B function and could also be used as an anticonvulsant in ...

FR-A 19
(CAS: 141099-46-9)

FR-A 19 is a Histamine H2 receptor agonist with potent anti-allergic properties. It can inhibit IgE-mediated human basophil histamine release in a nanomolar ran...

CAS 929622-08-2 Bavisant

(CAS: 929622-08-2)

Bavisant is a highly selective, orally active antagonist of the human H3 receptor. It is a novel mechanism of action, involving wakefulness and cognition. It ha...

CAS 184025-18-1 Ciproxifan

(CAS: 184025-18-1)

Ciproxifan is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.

CAS 58-33-3 Promethazine hydrochloride

Promethazine hydrochloride
(CAS: 58-33-3)

Promethazine hydrochloride is first-generation antihistamine of the phenothiazine family used as an antiallergic, in pruritus, for motion sickness and sedation,...

CAS 79516-68-0 Levocabastine

(CAS: 79516-68-0)

Levocabastine is a selective second-generation Histamine H1 receptor antagonist. It is used for Allergic conjunctivitis and Seasonal allergic rhinitis。Levocabas...

CAS 118288-08-7 Lafutidine

(CAS: 118288-08-7)

Lafutidine, a newly developed histamine H(2)-receptor antagonist, inhibits gastric acid secretion.

CAS 100299-08-9 Pemirolast potassium

Pemirolast potassium
(CAS: 100299-08-9)

Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent.

CAS 2438-32-6 Dexchlorpheniramine maleate

Dexchlorpheniramine maleate
(CAS: 2438-32-6)

Dexchlorpheniramine maleate, also known as Polaramine, is an antihistamine to treat allergic conditions, urticaria and allergic conjunctivitis and pruritus.

Chemical Structure

CAS 79516-68-0 Levocabastine

Quick Inquiry

Verification code

Featured Items