Levobunolol hydrochloride - CAS 27912-14-7
Catalog number: 27912-14-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C17H26ClNO3
Molecular Weight:
327.85
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Levobunolol hydrochloride, a beta1- and beta2-adregergic blocking agent, has proved to be an effective ocular hypotensive agent to treat glaucoma.
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Purity:
95%
Appearance:
Solid powder
Synonyms:
5-[(2R)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloride AKBeta Akorn Brand of Levobunolol Hydrochloride Allergan Brand of Levobunolol Hydrochloride Apo Levobunolol Apo-Levobunolol ApoLevobunolol Apotex Brand of Levobuno
Solubility:
Soluble to 10 mM in H2O
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -22℃ for long term (months to years).
MSDS:
Inquire
Shelf Life:
2 years
Quantity:
Data not available, please inquire.
Boiling Point:
464.4ºC at 760mmHg
Melting Point:
209-211 °C
InChIKey:
DNTDOBSIBZKFCP-UTONKHPSSA-N
InChI:
1S/C17H25NO3.ClH/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20;/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3;1H/t12-;/m1./s1
Canonical SMILES:
CC(C)(C)NCC(COC1=CC=CC2=C1CCCC2=O)O.Cl
1.Comparison of effects of topical levobunolol to a combination of timolol-dorzolamide on intraocular pressure and pulse rate of healthy dogs.
Pugliese M1, Scardillo A, Niutta PP, Pugliese A. Vet Res Commun. 2009 Sep;33 Suppl 1:205-7. doi: 10.1007/s11259-009-9273-9.
2.Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma.
Scardillo A1, Pugliese M, De Majo M, Niutta PP, Pugliese A. Vet Ther. 2010 Fall;11(3):E1-6.
The goal of glaucoma management is to reduce intraocular pressure (IOP) and maintain it at a level compatible with the health of the optic nerve. New therapies are constantly being sought. Topical instillation of levobunolol 0.5%, alone or with dorzolamide 2%, has a hypotensive effect on the IOP in healthy dogs, and levobunolol combined with dorzolamide produces a stronger hypotensive effect than the combination of timolol and dorzolamide. All animals tolerate these topical medications well with no signs of discomfort, and no ocular side effects have been observed. Levobunolol, alone or in combination with dorzolamide, induces bradycardia, as does timolol with dorzolamide.
3.Allergic contact dermatitis caused by timolol with cross-sensitivity to levobunolol.
Horcajada-Reales C1, Rodríguez-Soria VJ1, Suárez-Fernández R1. Contact Dermatitis. 2015 Dec;73(6):368-9. doi: 10.1111/cod.12448. Epub 2015 Jul 31.
4.Bradyarrhythmias secondary to topical levobunolol hydrochloride solution.
Lin L1, Wang Y1, Chen Y1, Liu M1. Clin Interv Aging. 2014 Oct 13;9:1741-5. doi: 10.2147/CIA.S69420. eCollection 2014.
An 88-year-old man was admitted with fatigue, dizziness, and heart palpitations. Both the electrocardiogram and Holter confirmed the existence of sinus bradycardia and sinus arrest. One hour prior to the onset of symptoms, he received levobunolol hydrochloride solution topically. The levobunolol hydrochloride solution was discontinued and the bradycardia resolved. He was diagnosed as having intermittent sinus bradycardia and sinus arrest, induced by topical β-blocker therapy. Levobunolol hydrochloride solution is an effective therapy for ocular hypertension, probably by reducing aqueous fluid production. However, it can induce cardiac side effects such as bradyarrhythmia and should be used with caution in elderly patients or patients with cardiac disease.
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CAS 27912-14-7 Levobunolol hydrochloride

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