Levetiracetam - CAS 102767-28-2
Catalog number:
Not Intended for Therapeutic Use. For research use only.
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Levetiracetam is an anticonvulsant medication used to treat epilepsy.
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UCB-L059, SIB-S1
1.A Comparison of Intravenous Levetiracetam and Valproate for the Treatment of Refractory Status Epilepticus in Children.
İşgüder R1, Güzel O2, Ceylan G3, Yılmaz Ü2, Ağın H3. J Child Neurol. 2016 Apr 14. pii: 0883073816641187. [Epub ahead of print]
Because of the lack of studies comparing the efficacy and safety of levetiracetam and valproate before the induction of general anesthesia in the treatment of convulsive refractory status epilepticus in children, we aimed to compare the effectiveness of these antiepileptic drugs in patients with convulsive status epilepticus admitted to the Pediatric Intensive Care Unit between 2011 and 2014. Forty-six (59%) of the 78 patients received levetiracetam, and 32 (41%) received valproate for the treatment of refractory status epilepticus. The response rate was not significantly different between the 2 groups. Although no adverse event was noted in patients who received levetiracetam, 4 (12.5%) patients in the valproate group experienced liver dysfunction (P= .025). According to our results, levetiracetam and valproate may be used in the treatment of refractory status epilepticus before the induction of general anesthesia. Levetiracetam appears as effective as valproate, and also safer.
2.Levetiracetam prophylaxis ameliorates seizure epileptogenesis after fluid percussion injury.
Chen YH1, Huang EY2, Kuo TT3, Hoffer BJ4, Wu PJ2, Ma HI5, Tsai JJ5, Chou YC6, Chiang YH7. Brain Res. 2016 Apr 19. pii: S0006-8993(16)30206-2. doi: 10.1016/j.brainres.2016.04.013. [Epub ahead of print]
To determine whether post-traumatic seizure severity would be affected by the interval between seizures and head injury, we measured seizures after various times with or without fluid percussion brain injury (2atm fluid percussion injury; FPI). To determine efficacy of anti-seizure medication, we also determined if levetiracetam (LEV) would alter the relationship between injury and subsequent seizures. Early post-traumatic seizures were induced by Kainic acid (KA) at one week after 2atm fluid percussion injury (FPI) in one group (FPI-ES). Seizures were induced at two weeks after FPI by KA in another group (FPI-LS). In addition, one group had induced seizures by KA without FPI, (sham-ES). Finally one group of animals received the antiepileptic agent (levetiracetam) infusion for one week after FPI and then had seizures induced by KA (FPI-LEV-ES). We measured seizure onset time, ictal duration and severity of seizures using a modified Racine's scale.
3.Levetiracetam Induced Drug Reaction with Eosinophilia and Systemic Symptom Syndrome.
Dar WR1, Sofi N2, Latief M2, Dar IA2, Kasana BA2. Indian J Dermatol. 2016 Mar-Apr;61(2):235. doi: 10.4103/0019-5154.177777.
Drug reaction with eosinophilia and systemic symptom syndrome (DRESS) is a hypersensitivity drug reaction, most frequently associated with antiepileptic drugs, characterized by skin rash, fever, pharyngitis, lymphadenopathy, and visceral organ involvement, typically presenting within 8 weeks of initiation of therapy. Management involves prompt withdrawal of the offending drug and use of systemic corticosteroids. We here present a rare case of DRESS secondary to levetiracetam. Only few case reports of DRESS secondary to levetiracetam have been published so far.
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CAS 102767-28-2 Levetiracetam

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