Levamisole - CAS 14769-73-4
Catalog number: 14769-73-4
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C11H12N2S
Molecular Weight:
204.29
COA:
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Targets:
Antibacterial
Description:
Levamisole, a thiazole derivative, has been found to be an antibiotic used to against parasitic worm infections and could also have potential activity in anticancer study.
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Purity:
98%
Appearance:
Powder
Synonyms:
(s)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole;L-6-PHENYL-2,3,5,6-TETRAHYDROIMIDAZOL(2,1-B) THIAZOLE;IMMUNOPURE(R) PHOSPHATASE SUPPRESSOR;LEVAMISOLE;LEVAMISOLE BASE;Imidazo2,1-bthiazole, 2,3,5,6-tetrahydro-6-phenyl-, (6S)-;lepuron;levomysol
Storage:
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
Inquire
Quality Standard:
In-house standard
Quantity:
Milligram-Grams
Density:
1.32 g/cm3
InChIKey:
HLFSDGLLUJUHTE-SNVBAGLBSA-N
InChI:
InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
Canonical SMILES:
C1CSC2=NC(CN21)C3=CC=CC=C3
1.Anthelmintic resistance in gastrointestinal nematodes of beef cattle in the state of Rio Grande do Sul, Brazil.
Ramos F1, Portella LP1, Rodrigues Fde S1, Reginato CZ1, Pötter L2, Cezar AS3, Sangioni LA1, Vogel FS1. Int J Parasitol Drugs Drug Resist. 2016 Feb 8;6(1):93-101. doi: 10.1016/j.ijpddr.2016.02.002. eCollection 2016.
Gastrointestinal nematodes resistant to anthelmintics have been reported in several regions of Brazil, and they may be associated with economic losses for the cattle industry. This study aimed to evaluate the resistance status of gastrointestinal nematodes from naturally infected beef cattle to several commercially available anthelmintics, as well as to test the efficacy of combinations of anthelmintics against multi-resistant gastrointestinal nematodes. Ten farms located in Rio Grande do Sul state were selected by: farmers' consent; extensive raising system; availability of calves aged from 7 to 9 months naturally infected by gastrointestinal nematodes; absence of anthelmintic treatment for 60 days before the study; and presence of 70-100 calves or more of both genders with ≥200 eggs per gram of feces (EPG) (sensitivity of 50 EPG). These calves were distributed into 10 groups (of 7-10 animals) per farm and treated with ivermectin, doramectin, eprinomectin, fenbendazole, closantel, nitroxynil, disophenol, levamisole, albendazole, or moxidectin.
2.[Cutaneous and mucosal manifestations associated with cocaine use].
Imbernón-Moya A1, Chico R2, Aguilar-Martínez A2. Med Clin (Barc). 2016 Mar 28. pii: S0025-7753(16)00099-3. doi: 10.1016/j.medcli.2016.02.015. [Epub ahead of print]
Complications due to cocaine are a public health problem. The typical cutaneous disease is leukocytoclastic vasculitis and/or thrombotic vasculopathy affecting mainly the ears. No intense systemic involvement is usually present, but there may be several cutaneous, mucosal and systemic manifestations. Other findings associated as arthralgia, neutropaenia or agranulocytosis, low titer positive antinuclear antibodies, antiphospholipid antibody positivity and neutrophil cytoplasmic antibodies against multiple antigens help the diagnosis. This disease requires a clinical suspicion with a clinical history, a complete physical examination and a broad differential diagnosis for an early and correct diagnosis. The course is usually self-limited. In most cases the only treatment is to discontinue the use of cocaine associated with symptomatic treatment, no proven benefit of systemic corticosteroids.
3.Effect of thermal treatments on the degradation of antibiotic residues in food.
Tian L1, Khalil S1, Bayen S1. Crit Rev Food Sci Nutr. 2016 Apr 6:0. [Epub ahead of print]
The thermal stability of antibiotics commonly detected in food is reviewed. To quantify degradation, two major techniques have been reported: liquid chromatography-based methods and microbiological tests. As the degradation products may also display some antimicrobial activity, microbiological tests may not be considered accurate analytical methods for quantifying antibiotic residues' degradation. Degradation percentages are summarized for different antibiotics and for various media (water, oil, milk and animal tissues). Studies presented in the literature confirm that the thermal degradation of β-lactams, quinolones, sulfonamides and tetracyclines can be described using a first-order kinetic model. Degradation rates, k, derived for this model for liquid matrix (water) at 100°C, followed the general trend amongst antibiotic classes: β-lactams = tetracyclines (most heat-labile) > lincomycin > amphenicols > sulfonamides > oxfendazole > levamisole (most heat-stable).
4.Necrotizing and crescentic glomerulonephritis with membranous nephropathy in a patient exposed to levamisole-adulterated cocaine.
Carrara C1, Emili S2, Lin M3, Alpers CE3. Clin Kidney J. 2016 Apr;9(2):234-8. doi: 10.1093/ckj/sfv141. Epub 2015 Dec 28.
Levamisole is an antihelminthic agent widely used as an adulterant of illicit cocaine recently implicated as a cause of antineutrophil cytoplasmic antibody (ANCA)-associated microscopic polyangiitis in cocaine abusers. An isolated case of membranous nephropathy (MN) associated with levamisole exposure has also been reported. We report the first case, to our knowledge, of a patient with both microscopic polyangiitis manifest as a pauci-immune necrotizing and crescentic glomerulonephritis and concurrent MN in the setting of chronic cocaine abuse and presumed levamisole exposure, raising the hypothesis that levamisole was the causative agent in the development of this rare dual glomerulopathy.
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CAS 14769-73-4 Levamisole

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