Leuconolam - CAS 93710-27-1
Catalog number: 93710-27-1
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
Molecular Weight:
Chemical Family:
Leuconolam comes from the herbs of Alstonia scholaris
Publictions citing BOC Sciences Products
  • >> More
Quality Standard:
Enterprise Standard
1.Total synthesis of (±)-leuconolam: intramolecular allylic silane addition to a maleimide carbonyl group.
Izgu EC;Hoye TR Chem Sci. 2013 Feb;4(5):2262-2266.
A concise total synthesis of the plant alkaloid (±)-leuconolam (1) has been achieved. A regio- and diastereoselective Lewis-acid mediated allylative cyclization was used to establish, simultaneously, two adjacent tetrasubstituted carbon centers. Furthermore, an essential arene cross-coupling to a hindered haloalkene was enabled by the use of a novel 2-anilinostannane.
2.Biosynthetically inspired divergent approach to monoterpene indole alkaloids: total synthesis of mersicarpine, leuconodines B and D, leuconoxine, melodinine E, leuconolam, and rhazinilam.
Yang Y;Bai Y;Sun S;Dai M Org Lett. 2014 Dec 5;16(23):6216-9. doi: 10.1021/ol503150c. Epub 2014 Nov 20.
Inspired by their potential biosynthesis, we have developed divergent total syntheses of seven monoterpene indole alkaloids including mersicarpine, leuconodines B and D, leuconoxine, melodinine E, leuconolam, and rhazinilam, and one unnatural analogue with an unprecedented structural skeleton. The key steps involve a Witkop-Winterfeldt oxidative indole cleavage followed by transannular cyclization. The transannular cyclization product was then converted to the corresponding structural skeletons by pairing its functional groups into different reaction modes.
3.Transformations of the 2,7-Seco Aspidosperma alkaloid leuconolam, structure revision of epi-leuconolam, and partial syntheses of leuconoxine and leuconodines A and F.
Low YY;Hong FJ;Lim KH;Thomas NF;Kam TS J Nat Prod. 2014 Feb 28;77(2):327-38. doi: 10.1021/np400922x. Epub 2014 Jan 15.
Several transformations of the seco Aspidosperma alkaloid leuconolam were carried out. The based-induced reaction resulted in cyclization to yield two epimers, the major product corresponding to the optical antipode of a (+)-meloscine derivative. The structures and relative configuration of the products were confirmed by X-ray diffraction analysis. Reaction of leuconolam and epi-leuconolam with various acids, molecular bromine, and hydrogen gave results that indicated that the structure of the alkaloid, previously assigned as epi-leuconolam, was incorrect. This was confirmed by an X-ray diffraction analysis, which revealed that epi-leuconolam is in fact 6,7-dehydroleuconoxine. Short partial syntheses of the diazaspiro indole alkaloid leuconoxine and the new leuconoxine-type alkaloids leuconodines A and F were carried out.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Alkaloids Products

CAS 82375-29-9 Humantenine

(CAS: 82375-29-9)

Humantenine may be found in the roots of Gelsemium elegans.

CAS 55610-01-0 Cepharadione A

Cepharadione A
(CAS: 55610-01-0)

Cepharadione A is an alkaloid compound found in the herbs of Piper longum. Cepharadione A is a naturally occurring DNA damaging agent.

CAS 73281-83-1 1,2-Dimethylquinolin-4-one-3-carboxylic acid

(CAS: 73281-83-1)

1,2-Dimethylquinolin-4-one-3-carboxylic acid isolated from the herbs of Micromelum sp.

CAS 114027-39-3 Humantenidine

(CAS: 114027-39-3)

Humantenidine is a natural alkaloid found in the herbs of Gelsemium sempervirens.

CAS 24697-74-3 Leonurine hydrochloride

Leonurine hydrochloride
(CAS: 24697-74-3)

Leonurine hydrochloride is an alkaloid that has been isolated from Leonotis leonurus (Lion's tail), Leonotis nepetifolia, Leonotis artemisia, Leonurus cardiaca ...

CAS 5140-42-1 Browniine

(CAS: 5140-42-1)

Browniine is an alkaloid isolated from delphinium brownii.

CAS 736140-70-8 1-(4-Methoxycinnamoyl)pyrrole

(CAS: 736140-70-8)

1-(4-Methoxycinnamoyl)pyrrole is an alkaloid isolated from Piper nigrum.

CAS 150710-72-8 Calyxamine B

Calyxamine B
(CAS: 150710-72-8)

Calyxamine B is a natural alkaloid found in the herbs of Salsola tetrandra.

CAS 2673-40-7 Vobasan-17-oic acid,4-demethyl-3-oxo-, methyl ester

Vobasan-17-oic acid,4-demethyl-3-oxo-, m
(CAS: 2673-40-7)

Perivine belongs to indole derivatives alkaloids. It comes from the oleander plants periwinkle (Catharanthus roseus G. Don) full grass. Animal experiments have ...

CAS 15266-38-3 Evocarpine

(CAS: 15266-38-3)

Evocarpine is a natural alkaloid compound found in several plants.

CAS 94-07-5 Synephrine

(CAS: 94-07-5)

Synephrine, that can be extracted from the young fruits Citrus aurantium L, is a drug product in Europe that was originally produced as a synthetic derivative o...

CAS 6859-01-4 Isorhynchophylline

(CAS: 6859-01-4)

Rhynchophylline and isorhynchophylline act as noncompetitive antagonists of the NMDA receptor and that this property may contribute to the neuroprotective and a...


Oxyperaksine is a natural organic compound.

CAS 132160-37-3 Glabredelphinine

(CAS: 132160-37-3)

CAS 169534-85-4 Protostemotinine

(CAS: 169534-85-4)

CAS 19408-84-5 Dihydrocapsaicin

(CAS: 19408-84-5)

The dietary fat increases the bioaccessibility of capsaicin and Dihydrocapsaicin in digestions with red peppers, especially that of Dihydrocapsaicin.

CAS 90038-21-4 Tatsinine

(CAS: 90038-21-4)

CAS 52389-15-8 Epistephamiersine

(CAS: 52389-15-8)

Epistephamiersine isolated from the roots of Stephania japonica.

Chemical Structure

CAS 93710-27-1 Leuconolam

Quick Inquiry

Verification code

Featured Items