Lercanidipine - CAS 100427-26-7
Catalog number: 100427-26-7
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C36H41N3O6
Molecular Weight:
611.73
COA:
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Targets:
Calcium Channel
Description:
Lercanidipine hydrochloride, a dihydropyridine compound, is a third generation calcium channel antagonist which shows longer duration of action of the past two generations' in the treatment of mild-to-moderate hypertension.
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Purity:
95%
Appearance:
White to light yellow solid
Synonyms:
Lercanidipine;100427-26-7;Lercanidipine[INN];masnidipine;Lercanil(TN);Lercanidipine(INN)
Solubility:
10 mM in DMSO
Storage:
-20 ºC Freeze
MSDS:
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Application:
Lercanidipine hydrochloride is a third generation calcium channel antagonist which shows longer duration of action of the past two generations' in the treatment of mild-to-moderate hypertension.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
712.5ºC at 760 mmHg
Melting Point:
118-120ºC
Density:
1.177 g/cm3
InChIKey:
ZDXUKAKRHYTAKV-UHFFFAOYSA-N
InChI:
InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3
Canonical SMILES:
CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC
1.Development and validation of reversed phase high-performance liquid chromatography method for estimation of lercanidipine HCl in pure form and from nanosuspension formulation.
Chonkar AD1, Managuli RS1, Rao JV2, Udupa N3. J Basic Clin Pharm. 2015 Dec;7(1):17-22. doi: 10.4103/0976-0105.170586.
AIM: Quantitative estimation of lercanidipine HCl in bulk material as well as from nanosuspension formulations via a developed reverse phase HPLC method.
2.Adverse event potentially due to an interaction between ibrutinib and verapamil: a case report.
Lambert Kuhn E1, Levêque D1, Lioure B2, Gourieux B1, Bilbault P3. J Clin Pharm Ther. 2016 Feb;41(1):104-5. doi: 10.1111/jcpt.12355.
WHAT IS KNOWN AND OBJECTIVE: Ibrutinib is a recently approved oral anticancer agent with pharmacokinetics that is very sensitive to metabolic inhibition. We report a serious side effect of ibrutinib potentially attributable to interaction with the moderate CYP3A4 inhibitor verapamil.
3.Development of Fast Dissolving Oral Films Containing Lercanidipine HCl Nanoparticles in Semicrystalline Polymeric Matrix for Enhanced Dissolution and Ex Vivo Permeation.
Chonkar AD1, Venkat Rao J2, Managuli RS1, Mutalik S1, Dengale S3, Jain P2, Udupa N4. Eur J Pharm Biopharm. 2016 Apr 5. pii: S0939-6411(16)30125-4. doi: 10.1016/j.ejpb.2016.04.001. [Epub ahead of print]
Lercanidipine is a vasoselective dihydropyridine calcium antagonist, mainly used for the treatment of hypertension and angina pectoris. However, it suffers from food dependent absorption, poor solubility, low permeability and considerable first pass metabolism, resulting in highly variable and low bioavailability of 10%. Nanoparticles of lercanidipine were incorporated in fast dissolving oral films (FDO) via preparation of nanosuspension by evaporative antisolvent precipitation method. Prepared nanosuspensions were incorporated in FDO without lyophilizing or spray drying. Two nanosuspensions containing PEG 400 and TPGS 1000 as stabilizers, selected further for incorporation in FDO. Physicochemical and mechanical properties of the optimised films were observed to be within acceptance criteria. SEM images as well as FTIR chemical images of oral films show uniform distribution of nano-particles in polymeric matrix. The DSC and XRD results proved the poorly crystalline nature of lercanidipine.
4.Combined mixture-process variable approach: a suitable statistical tool for nanovesicular systems optimization.
Habib BA1, AbouGhaly MH1. Expert Opin Drug Deliv. 2016 Apr 4:1-12. [Epub ahead of print]
OBJECTIVES: This study aims to illustrate the applicability of combined mixture-process variable (MPV) design and modeling for optimization of nanovesicular systems.
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Chemical Structure

CAS 100427-26-7 Lercanidipine

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