LEQ-506 - CAS 1204975-42-7
Catalog number:
1204975-42-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H32N6O
Molecular Weight:
432.57
COA:
Inquire
Targets:
Smo
Description:
This active molecular is a Smoothened (Smo) antagonist with potential antitumor activity. LEQ506 selectively binds to the Hedgehog(Hh) ligand cell surface receptor Smo to inhibited tumor cell growth through suppressing the Hh signaling pathway, Till Jul 2016, no reports of development identified for phase-I development in Solid-tumours were published yet
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Purity:
98%
Appearance:
Powder
Synonyms:
2-[5-[(2R)-4-(6-benzyl-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl]pyrazin-2-yl]propan-2-ol;UNII-6SJX1T5HJD; 6SJX1T5HJD; NVP-LEQ506; NVP-LEQ-506; SCHEMBL1140459
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
Solid tumors
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
POERAARDVFVDLO-QGZVFWFLSA-N
InChI:
InChI=1S/C25H32N6O/c1-17-16-30(11-12-31(17)23-15-26-22(14-27-23)25(4,5)32)24-19(3)18(2)21(28-29-24)13-20-9-7-6-8-10-20/h6-10,14-15,17,32H,11-13,16H2,1-5H3/t17-/m1/s1
Canonical SMILES:
CC1CN(CCN1C2=NC=C(N=C2)C(C)(C)O)C3=NN=C(C(=C3C)C)CC4=CC=CC=C4
Current Developer:
Originator: Novartis
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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