|Description||This active molecular is a Smoothened (Smo) antagonist with potential antitumor activity. LEQ506 selectively binds to the Hedgehog（Hh） ligand cell surface receptor Smo to inhibited tumor cell growth through suppressing the Hh signaling pathway, Till Jul 2016, no reports of development identified for phase-I development in Solid-tumours were published yet|
|Synonyms||2-[5-[(2R)-4-(6-benzyl-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl]pyrazin-2-yl]propan-2-ol;UNII-6SJX1T5HJD; 6SJX1T5HJD; NVP-LEQ506; NVP-LEQ-506; SCHEMBL1140459|
|Solubility||Soluble in DMSO|
|Quality Standard||In-house standard|
|Shelf Life||2 month in rt, long time|
|Current Developer||Originator: Novartis|
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This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing gr...
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This active molecular is a Smoothened (Smo) antagonist with potential antitumor activity. LEQ506 selectively binds to the Hedgehog（Hh） ligand cell surface recep...
MRT-92 HCl salt
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