|Description||Lenalidomideis a derivative of thalidomide introduced in 2004. Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.|
|Synonyms||Revlimid hydrochloride; CC-5013 hydrochloride; CC5013 hydrochloride; CC 5013 hydrochloride|
CPI-1189 is an inhibitor of TNF-α release with the potential use to treat sciatica and postherpetic neuralgia.
Bioymifi is a potent and selective death receptor 5 (DR5) activator. Bioymifi works by mimicking the ability of TRAIL to stimulate clustering of DR5, triggering...
SPD 304 a cell-permeable inhibitor of tumor necrosis factor-α (TNFα, IC50 = 22 μM), which is a modulator of inflammation conditions such as rheumatoid arthritis...
Pomalidomide is an analog of thalidomide, a TNF-α production inhibitor. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibitin...
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). It was shown to inhibit TNF-α-induced cytotoxicity in L929 fibroblast cells, attenuate inflammation and incr...
BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction o...
Magnolol is a bioactive lignin found in Magnolia officinalis and acts as a TNF-α and nitric oxide (NO) inhibitor. It exhibits potential therapeutic effect on an...
GW-3333 is a dual inhibitors of tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) and matrix metalloproteinases.