|Targets||PROTAC | TNF-alpha|
|Description||Lenalidomide is an analog of thalidomide, a TNF-α production inhibitor. Lenalidomide can be utilized in PROTAC as an E3 ligase ligand for targeting cereblon, inducing ubiquitination and degradation of casein kinase (CK) 1α by E3 ubiquitin ligase. Lenalidomide has been developed for the treatment of multiple myeloma and myelodysplastic syndromes (MDS).|
|Shelf Life||2 years|
|Melting Point||>250ºC (dec.)|
TL 13-27 is a negative control of TL 12-186.
DCVC has been found to influence sort of cytokines release stimulated by pathogen.
Pomalidomide-C6-PEG3-butyl azide is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with ter...
Pomalidomide-PEG2-butyl iodide is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with termi...
Lenalidomideis a derivative of thalidomide introduced in 2004. Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
BMS561392 is a tumor necrosis factor-alpha (TNF alpha) converting enzyme inhibitor. It has the potential treatment of diseases characterized by overproduction o...
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM.
(S,R,S)-AHPC-C6-CO2H hydrochloride is a crosslinker−E3 ligase ligand conjugate consisting of a von Hippel-Lindau (VHL)-recruiting ligand and an alkyl chain link...
Necrostatin 2 racemate
Necrostatin 2 racemate is the racemate of Necrostatin, which is a potent necroptosis inhibitor.
(S,R,S)-AHPC-PEG2-azide is a crosslinker−E3 ligase ligand conjugate consisting of a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with t...
Magnolol is a bioactive lignin found in Magnolia officinalis and acts as a TNF-α and nitric oxide (NO) inhibitor. It exhibits potential therapeutic effect on an...
Ginsenoside Rg5, a main constituent isolated from red ginseng, exhibits anti-inflammatory property as in LPS-stimulated alveolar macrophages it inhibited the ex...
Necrostatin 2 is a potent necroptosis inhibitor. It is a potent in vitro necroptosis inhibitors and is also efficacious in an animal model of ischemic stroke.
Hispidol ((Z)-Hispidol) inhibits TNF-α induced adhesion of monocytes to colon epithelial cells (IC50= 0.50 µM) and is a potential therapeutic for inflammatory b...
C 87 is a TNF-α inhibitor (Kd = 110 nM for hTNF-α). It was shown to inhibit TNF-α-induced cytotoxicity in L929 fibroblast cells, attenuate inflammation and incr...
Pomalidomide-PEG4-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a PEGylated crosslinker with terminal carb...
TL 12-186 is a multikinase degrading PROTAC consisting of a kinase inhibitor conjugated to the cereblon E3 ubiquitin ligase ligand pomalidomide.
Pomalidomide-C3-CO2H is a crosslinker-E3 ligase ligand conjugate consisting of an E3 ligase ligand pomalidomide and a short alkyl chain linker. It has been used...
Protein degrader 1 hydrochloride
Protein degrader 1 hydrochloride is a building block used in the synthesis of PROTAC for the recruitment of the von Hippel-Lindau (VHL) protein.
Protac-1 is composed of the IκBα phosphopeptide that is recognized by the F-box protein β-TRCP, and ovalicin. MetAP-2 can be tethered to SCFβ-TRCP, ubiquitinate...