Lemon Oil - CAS 8008-56-8
Lemon Oil is commonly used in aromatherapy and as a flavorant.
1.Hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxication.
Kim TW1, Lee DR2, Choi BK2, Kang HK1, Jung JY1, Lim SW3, Yang SH4, Suh JW5. Food Chem Toxicol. 2016 May;91:91-9. doi: 10.1016/j.fct.2016.03.004. Epub 2016 Mar 12.
In the present study, we explore the protective effects of Citrus aurantium L. extract (CAE) against acute and chronic CCl4-induced hepatotoxicity. The quantitative analysis of CAE was performed using HPLC-UV to determine the nobiletin content was approximately 27%. For the acute model, the male ICR mice were orally treated with water, silymarin (positive control, 200 mg/kg) and CAE (50 and 200 mg/kg) for 3 days prior to CCl4 (1 mL/kg, 50% v/v in olive oil) IP injection. For the chronic model (n = 6/group), the mice were treated with each treatment for 28 consecutive days and CCl4 (1 mL/kg, 20%) was injected twice a week. In both the acute and chronic models, the CCl4 alone treated group showed histopathologic alterations with a significantly increase in serum hepatic enzyme levels together with a disrupted anti-oxidative status. In contrast, the CAE treatments restored pathologic alterations and recovered the oxidative status by enhancing antioxidant enzymes and reducing lipid peroxidation levels.
2.Development of a Microemulsion Formulation for Antimicrobial SecA Inhibitors.
Hu J1, Akula N1, Wang N1. PLoS One. 2016 Mar 10;11(3):e0150433. doi: 10.1371/journal.pone.0150433. eCollection 2016.
In our previous study, we have identified five antimicrobial small molecules via structure based design, which inhibit SecA of Candidatus Liberibacter asiaticus (Las). SecA is a critical protein translocase ATPase subunit and is involved in pre-protein translocation across and integration into the cellular membrane in bacteria. In this study, eleven compounds were identified using similarity search method based on the five lead SecA inhibitors identified previously. The identified SecA inhibitors have poor aqueous solubility. Thus a microemulsion master mix (MMX) was developed to address the solubility issue and for application of the antimicrobials. MMX consists of N-methyl-2-pyrrolidone and dimethyl sulfoxide as solvent and co-solvent, as well as polyoxyethylated castor oil, polyalkylene glycol, and polyoxyethylene tridecyl ether phosphate as surfactants. MMX has significantly improved the solubility of SecA inhibitors and has no or little phytotoxic effects at concentrations less than 5.
3.The physico-chemical properties of some citrus seeds and seed oils.
Juhaimi FA, Matthäus B, Özcan MM, Ghafoor K. Z Naturforsch C. 2016 Mar 26. pii: /j/znc.ahead-of-print/znc-2016-0004/znc-2016-0004.xml. doi: 10.1515/znc-2016-0004. [Epub ahead of print]
The chemical properties, mineral contents, fatty acid and tocopherol contents of seed and seed oils of some citrus genus provided from several locations in Turkey and Saudi Arabia were determined. While Ca contents of seeds were between 5018 mg/kg (Kütdiken lemon) and 7619 mg/kg (kinnow mandarin), K contents of seeds varied between 7007 mg/kg (Orlando orange) and 10334 mg/kg (kinnow mandarin). Glucose and fructose contents of citrus seed samples varied between 3.75 g/kg and 5.75 g/kg, and 4.09 g/kg and 6.03 g/kg. Palmitic, oleic and linoleic acids were established as dominant fatty acids. Palmitic, oleic and linoleic acid contents of citrus seed oils varied between 19.6% (Kütdiken lemon) and 26.2% (pineapple orange), 21.3% (kinnow mandarin) and 31.4% (Kütdiken lemon) and 32.3% (Kütdiken lemon) and 43.7% (kinnow mandarin), respectively. The total amount of tocopherols of Turkish citrus oil varied between 0.5 mg/100 g (Fremont mandarin) and 18.
4.Larvicidal potential of essential oils against Musca domestica and Anopheles stephensi.
Chauhan N1, Malik A2, Sharma S3, Dhiman RC4. Parasitol Res. 2016 Feb 26. [Epub ahead of print]
The larvicidal activity of Mentha piperita, Cymbopogan citratus (lemongrass), Eucalyptus globulus and Citrus sinensis (orange) essential oils and their combinations was evaluated against Musca domestica (housefly) and Anopheles stephensi (mosquitoes) through contact toxicity assay. Among all the tested essential oils/combinations, Me. piperita was found to be the most effective larvicidal agent against Mu. domestica and An. stephensi with LC50 values of 0.66 μl/cm2 and 44.66 ppm, respectively, after 48 h. The results clearly highlighted that the addition of mentha oil to other oils (1:1 ratio) improved their larvicidal activity. The order of effectiveness of essential oils/combinations indicated that the pattern for An. stephensi follows the trend as mentha > mentha + lemongrass > lemongrass > mentha + eucalyptus > eucalyptus > mentha + orange > orange and for Mu. domestica as mentha > mentha + lemongrass > lemongrass > mentha + orange > orange > mentha + eucalyptus > eucalyptus.
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CAS 8008-56-8 Lemon Oil

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