Lemborexant - CAS 1369764-02-2
Catalog number:
1369764-02-2
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H20F2N4O2
Molecular Weight:
410.42
COA:
Inquire
Targets:
Orexin Receptor (OX Receptor)
Description:
Lemborexant, an orexin OX1/OX2 receptors antagonist, has been found to be effective against insomnia and is just planed a Phase III trail by Eisai.
Publictions citing BOC Sciences Products
  • >> More
Purity:
98%
Appearance:
Powder
Synonyms:
Lemborexant; UNII-0K5743G68X; Lemborexant [INN]; SCHEMBL2116558; CHEMBL3545367; 0K5743G68X
Solubility:
DMSO: ≥ 30 mg/mL
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Lemborexant is an orexin OX1/OX2 receptors antagonist that has been found to be effective against insomnia and is just planed a Phase III trail by Eisai.
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
InChIKey:
MUGXRYIUWFITCP-PGRDOPGGSA-N
InChI:
InChI=1S/C22H20F2N4O2/c1-13-19(11-25-14(2)27-13)30-12-22(15-4-3-5-16(23)8-15)9-18(22)21(29)28-20-7-6-17(24)10-26-20/h3-8,10-11,18H,9,12H2,1-2H3,(H,26,28,29)/t18-,22+/m0/s1
Canonical SMILES:
CC1=NC(=NC=C1OCC2(CC2C(=O)NC3=NC=C(C=C3)F)C4=CC(=CC=C4)F)C
Current Developer:
Eisai
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Orexin Receptor (OX Receptor) Products


CAS 913358-93-7 Almorexant HCl

Almorexant HCl
(CAS: 913358-93-7)

Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, re...

CAS 916141-36-1 TCS 1102

TCS 1102
(CAS: 916141-36-1)

TCS 1102 is a potent, dual orexin receptor antagonist with Ki values of 0.2 and 3 nM for OX2 and OX1 receptors respectively. It is a poor substrate for P-glycop...

Lemborexant
(CAS: 1369764-02-2)

Lemborexant, an orexin OX1/OX2 receptors antagonist, has been found to be effective against insomnia and is just planed a Phase III trail by Eisai.

Filorexant
(CAS: 1088991-73-4)

Filorexant, a selective reversible and orally bioavaliable antagonist of OX(1)R receptor and OX(2)R receptor, could probably be an effective compound in the tre...

CAS 1610882-30-8 TCS-OX2-29 HCl

TCS-OX2-29 HCl
(CAS: 1610882-30-8)

TCS-OX2-29, also known as TCSOX229, is a selective OX2 receptor antagonist (IC50 = 40 nM, pKi = 7.5) with >250-fold selectivity for hOX2R compared with hOX1R (I...

CAS 288150-92-5 SB408124

SB408124
(CAS: 288150-92-5)

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity ove...

Orexin 2 Receptor Agonist
(CAS: 1796565-52-0)

N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide is an orexin 2 receptor agonist that is potentially for...

SB-408124 (Hydrochloride)
(CAS: 1431697-90-3)

SB-408124 (Hydrochloride) is the hydrochloride salt form of SB-408124. SB-408124 is a selective antagonist of OX1 (for human OX1 Kb= 21.7nM; for human OX2 Kb=14...

CAS 380899-24-1 SB-649868

SB-649868
(CAS: 380899-24-1)

SB-649868 is a novel, orally active dual orexin receptor antagonist of orexin(OX)1 and OX2 receptor (pKi=9.4 and 9.5 at the OX1 and OX2 receptor, respectively),...

CAS 1373765-19-5 IPSU

IPSU
(CAS: 1373765-19-5)

IPSU is a selective, orally available and brain penetrant OX2 receptor antagonist (pKi= 7.85) with 6-fold selectivity over OX1 receptors.

CAS 483313-22-0 SB-674042

SB-674042
(CAS: 483313-22-0)

SB-674042 is potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM), by binding with high affinity to OX1R and mediates intracellular ca...

CAS 1224846-01-8 MK-3697

MK-3697
(CAS: 1224846-01-8)

MK3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists (2-SORAs) that possess acceptable profiles for clinical development. MK-3...

CAS 792173-99-0 SB334867

SB334867
(CAS: 792173-99-0)

SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2.

JNJ-10397049
(CAS: 708275-58-5)

JNJ-10397049 is a selective orexin-2 receptor (OX2) antagonist. pIC50 is 7.4 for chimeric OX2 receptors/ pKB values are 5.9 for OX1 and 8.5 for OX2 receptors re...

CAS 871224-64-5 Almorexant

Almorexant
(CAS: 871224-64-5)

Almorexant(ACT078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and ...

CAS 249889-64-3 SB-334867

SB-334867
(CAS: 249889-64-3)

SB-334867, with sedative and anorectic effects, it is the first non-peptide selective antagonist of orexin receptor subtype OX1 (pKb= 7.2) with 50 -fold selecti...

Quick Inquiry

Verification code

Featured Items