LEE011 succinate - CAS 1374639-75-4
Catalog number: 1374639-75-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C27H36N8O5
Molecular Weight:
552.63
COA:
Inquire
Targets:
CDK
Description:
LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.
Purity:
>98%
Synonyms:
Ribociclib succinate; LEE 011 succinate; LEE-011 succinate
MSDS:
Inquire
InChIKey:
NHANOMFABJQAAH-UHFFFAOYSA-N
InChI:
InChI=1S/C23H30N8O.C4H6O4/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;5-3(6)1-2-4(7)8/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1-2H2,(H,5,6)(H,7,8)
Canonical SMILES:
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5.C(CC(=O)O)C(=O)O
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related CDK Products


CAS 571190-30-2 Palbociclib

Palbociclib
(CAS: 571190-30-2)

Palbociclib is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-depen...

QS-1189

QS-1189 is a reversible, high selective, orally available cyclin-dependent kinase 7 (CDK7) inhibitor developed for cancer therapy. QS-1189 exhibits antitumor ac...

CAS 942425-68-5 PHA-767491 hydrochloride

PHA-767491 hydrochloride
(CAS: 942425-68-5)

PHA-767491 hydrochloride is a potent, ATP-competitive dual Cdc7/Cdk9 inhibitor, which prevents initiation of DNA replication. It inhibits cell proliferation in ...

CAS 602306-29-6 AZD5438

AZD5438
(CAS: 602306-29-6)

AZD5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol/L, respectively). Broad cdk inhibition may provide an eff...

CAS 1401033-86-0 AMG 925

AMG 925
(CAS: 1401033-86-0)

AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. AMG 925 inhibited AML xenograft tumor growth by 96...

KH-CB19
(CAS: 1354037-26-5)

KH-CB19, a CLK1/CLK4 inhibitor, has been found to probably restrain the phosphorylation of serine- and arginine-rich (SR) proteins. IC50: 20 nM for CLK1.

CAS 1269815-17-9 CDK-IN-2

CDK-IN-2
(CAS: 1269815-17-9)

CDK-IN-2 is a potent and sepecific CDK inhibitor.

BS 181 dihydrochloride

BS 181 dihydrochloride is a selective CDK7 inhibitor (IC50 = 21 nM) displaying >40-fold selectivity for CDK7 over others CDKs. BS 181 promotes cell cycle arrest...

Chemical Structure

CAS 1374639-75-4 LEE011 succinate

Quick Inquiry

Verification code

Featured Items