LDN-212320 - CAS 894002-50-7
Catalog number: 894002-50-7
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C17H15N3S
Molecular Weight:
293.39
COA:
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Targets:
EAAT2
Description:
LDN-212320 is a glutamate transporter EAAT2 activator. It increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells and displays neuroprotective activity in vivo. It is shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.
Purity:
>98%
Synonyms:
LDN/OSU-0212320; LDN-0212320; OSU-0212320; LDN-212320; LDN 212320; LDN212320
MSDS:
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InChIKey:
DUUQLWDHNYFUPP-UHFFFAOYSA-N
InChI:
InChI=1S/C17H15N3S/c1-13-6-2-3-7-14(13)12-21-17-10-9-16(19-20-17)15-8-4-5-11-18-15/h2-11H,12H2,1H3
Canonical SMILES:
CC1=CC=CC=C1CSC2=NN=C(C=C2)C3=CC=CC=N3
1.4'-Phenyl-3,4-di-hydro-2H-spiro-[naph-tha-lene-1,3'-[1,2,4]triazole]-5'-thione.
Mague JT;Akkurt M;Mohamed SK;Hassan AA;Albayati MR Acta Crystallogr Sect E Struct Rep Online. 2014 May 31;70(Pt 6):o740-1. doi: 10.1107/S1600536814012409. eCollection 2014 Jun 1.
In the title mol-ecule, C17H15N3S, the phenyl group makes a dihedral angle of 57.29 (11)° with the mean plane of the triazole ring, which in turn makes an angle of 86.83 (12)° with the plane of the aromatic portion of the tetra-hydro-naphthalene moiety. In the crystal, mol-ecules are linked by weak C-H⋯S hydrogen bonds into supra-molecular chains propagating along the a-axis direction. Weak C-H⋯π inter-actions are also observed.
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CAS 894002-50-7 LDN-212320

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