LDN-193189 - CAS 1062368-24-4
Catalog number:
1062368-24-4
Category:
Stem Cell Molecule
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H22N6 · HCl
Molecular Weight:
442.94
COA:
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Description:
LDN193189 is a derivative of dorsomorphin that is a highly selective antagonist of BMP receptor isotypes ALK2 and ALK3 (IC50 of: 5 and 30 nM). The selectivity of LDN193189 for ALK2/3 is 200 fold over the TGF-B type receptors ALK4,-5 and -7. In murine smooth muscle cells, the compound inhibits BMP-4 induced phosphorylation of SMAD 1/5/8 with an IC50 of 5 nM.
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Purity:
0.98
Related CAS:
1062368-62-0 (HCl); 1435934-00-1 (dihydrochloride)
Appearance:
Solid powder
Synonyms:
4-[6-(4-Piperazin-1-yl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline; LDN193189; LDN 193189; LDN-193189
MSDS:
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Application:
Differentiation
InChIKey:
CDOVNWNANFFLFJ-UHFFFAOYSA-N
InChI:
1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
Canonical SMILES:
C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16
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Chemical Structure

CAS 1062368-24-4 LDN-193189

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