Laropiprant - CAS 571170-77-9
Catalog number:
571170-77-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C21H19ClFNO4S
Molecular Weight:
435.91
COA:
Inquire
Targets:
Prostaglandin Receptor
Description:
Laropiprant is a potent, selective DP1 receptor antagonist (Ki=0.57 nM) used in combination with niacin to reduce blood cholesterol (LDL and VLDL).
Publictions citing BOC Sciences Products
  • >> More
Purity:
≥95%
Appearance:
White to off-white solid
Synonyms:
MK-0524; (3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-cyclopent[b]indole-3-acetic acid 2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A potent, selective DP1 receptor antagonist
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
173-176 °C
InChIKey:
NXFFJDQHYLNEJK-CYBMUJFWSA-N
InChI:
1S/C21H19ClFNO4S/c1-29(27,28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12/h2-3,5-6,9-10,13H,4,7-8,11H2,1H3,(H,25,26)/t13-/m1/s1
Canonical SMILES:
CS(=O)(=O)C1=C2C(=CC(=C1)F)C3=C(N2CC4=CC=C(C=C4)Cl)C(CC3)CC(=O)O
Current Developer:
Merck & Co
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Prostaglandin Receptor Products


CAS 892549-43-8 Mf-63

Mf-63
(CAS: 892549-43-8)

Mf-63 is a selective Microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Its IC50 value is 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, r...

AM-211 sodium
(CAS: 1263077-74-2)

This active molecular is a potent Prostaglandin D2 receptor antagonists and has been in phase I clinical trials for both COPD (chronic obstructive pulmonary dis...

CAS 915191-42-3 MF498

MF498
(CAS: 915191-42-3)

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, a Gs protein-coupled receptor, with Ki of 0.7 nM. It plays important roles in ...

FR-181157
(CAS: 200433-03-0)

FR-181157 is an orally active prostacyclin mimetic that shows high potency and agonist efficacy at the IP receptor.

CAS 851723-84-7 OC000459

OC000459
(CAS: 851723-84-7)

OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM.

CAS 223488-57-1 CP-533536

CP-533536
(CAS: 223488-57-1)

CP-533536, also called as Evatanepag, a 3-pyridyl sulfonamide compound, demonstrated excellent in vitro potency against prostaglandin E2 (PGE2) (induces local b...

CAS 62561-03-9 (+)-Cloprostenol sodium salt

(+)-Cloprostenol sodium salt
(CAS: 62561-03-9)

(+)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol, which is an aryl-oxymethyl analog of prostaglandin F2α. It has luteolytic effects and is used ...

CAS 402473-54-5 ONO-AE3-208

ONO-AE3-208
(CAS: 402473-54-5)

ONO-AE3-208 is an EP4 antagonist (Ki values are 1.3, 30, 790 and 2400 nM for EP4, EP3, FP and TP receptors respectively), which less potently affects EP3, FP, a...

CAS 847728-01-2 CJ-42794

CJ-42794
(CAS: 847728-01-2)

CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist. It inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5. It ...

CAS 745-65-3 Prostaglandin-E1

Prostaglandin-E1
(CAS: 745-65-3)

Prostaglandin-E1 is used as a drug in the treatment of erectile dysfunction and has vasodilatory properties. It can be used as a vasodilator agent increasing pe...

CAS 439288-66-1 GW 627368X

GW 627368X
(CAS: 439288-66-1)

GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, resp...

CAS 59122-46-2 Misoprostol

Misoprostol
(CAS: 59122-46-2)

Misoprostol, a synthetic analog of natural prostaglandin E1, is an effective anti-ulcer agent and also has oxytocic properties.

CAS 752187-80-7 CP 544326

CP 544326
(CAS: 752187-80-7)

CP 544326, also known as taprenepag, is a potent and selective EP(2) receptor agonist. Its EC50 value is 2.8 nM. It is the active acid metabolite of the prodrug...

CAS 415903-37-6 Grapiprant (CJ-023423)

Grapiprant (CJ-023423)
(CAS: 415903-37-6)

Grapiprant, also known as CJ-023,423, RQ-00000007 and AAT-007, is a novel, potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic prop...

PF-04418948
(CAS: 1078166-57-0)

PF-04418948 is a potent and selective prostaglandin EP₂ receptor antagonist with IC50 of 16 nM. Phase 1. PF-04418948 antagonizes the effects of butaprost and PG...

Terutroban
(CAS: 165538-40-9)

Terutroban is a potent, orally active antagonist of the thromboxane/prostaglandin A2(TP) receptor (IC50 = 16.4 nM). In guinea pigs it also inhibits U 46619 indu...

CAS 72814-32-5 BW 245C

BW 245C
(CAS: 72814-32-5)

BW 245C, a prostaglandin analogue, is a selective prostanoid DP-receptor (DP1)agonist used to treat stroke where the Ki for the inhibition of [3H]-PGD2 binding ...

Fevipiprant
(CAS: 872365-14-5)

Fevipipran is a reversible competitive CRTh2 antagonist with IC50 value of 0.44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood. ...

CAS 571170-77-9 Laropiprant

Laropiprant
(CAS: 571170-77-9)

Laropiprant is a potent, selective DP1 receptor antagonist (Ki=0.57 nM) used in combination with niacin to reduce blood cholesterol (LDL and VLDL).

CAS 55028-72-3 Cloprostenol sodium

Cloprostenol sodium
(CAS: 55028-72-3)

Cloprostenol sodium is a synthetic and water-soluble aryl-oxymethyl analog of prostaglandin F2α. lt is also a potent inhibitor of rat adipose precursor differen...

Chemical Structure

CAS 571170-77-9 Laropiprant

Quick Inquiry

Verification code

Featured Items