|Description||Laropiprant is a potent, selective DP1 receptor antagonist (Ki=0.57 nM) used in combination with niacin to reduce blood cholesterol (LDL and VLDL).|
|Appearance||White to off-white solid|
|Synonyms||MK-0524; (3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-cyclopent[b]indole-3-acetic acid 2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid;|
|Solubility||Soluble in DMSO|
|Storage||Store at -20 °C|
|Application||A potent, selective DP1 receptor antagonist|
|Quality Standard||Enterprise Standard|
|Shelf Life||As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly|
|Melting Point||173-176 °C|
|Current Developer||Merck & Co|
A EP1 antagonist (pKi= 7.54) (pIC50= 8.5)
GSK-345931A is an EP(1) receptor antagonist. It is efficient in preclinical models of inflammatory pain.
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MK-2894 Na salt
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MK 0524 sodium salt
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Laropiprant is a potent, selective DP1 receptor antagonist (Ki=0.57 nM) used in combination with niacin to reduce blood cholesterol (LDL and VLDL).
This active molecular is a prostaglandin receptor agonist and detailed information has not been published yet.
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OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM.
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S 5751 is a potent and orally bioactive antagonist of prostaglandin D2 (PGD2) receptor DP1 (Ki values 1.6 and 24.2 nM for human DP and TP receptors, respectivel...
(+)-Cloprostenol sodium salt
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Ethamsylate is a haemostatic drug, which inhibits biosynthesis and action of prostaglandins, and increases capillary endothelial resistance as and platelet adhe...