Lanopepden - CAS 1152107-25-9
Catalog number:
1152107-25-9
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C22H34FN7O4
Molecular Weight:
479.58
COA:
Inquire
Targets:
Others
Description:
This active molecular is a selective peptide deformylase inhibitor. It has good anti-bacteria activity in vitro. Antibacterial spectrum of Lanopepden includes S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. It can also used to the treatment of infectious diseases caused by drug-resistant pathogens. In Jan 1st 2015, GlaxoSmithKline withdrew phase I trial in Bacterial infections in USA. In 26th Jan 2015,GlaxoSmithKline withdrew a phase I pharmacokinetics/pharmacodynamics trial in Healthy volunteers in USA.
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Purity:
98%
Appearance:
Powder
Synonyms:
N-[(2R)-2-(cyclopentylmethyl)-3-(2-{5-fluoro- 6-[(9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]- 2-methylpyrimidin-4-yl}hydrazin-1-yl)-3-oxopropyl]- N-hydroxyformamide,GSK-1322322,GSK-322
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
the treatment of infectious diseases caused by drug-resistant pathogens.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
SWHNZGMQMGFQGW-MSOLQXFVSA-N
InChI:
InChI=1S/C22H34FN7O4/c1-15-24-20(19(23)21(25-15)29-7-6-28-8-9-34-13-18(28)12-29)26-27-22(32)17(11-30(33)14-31)10-16-4-2-3-5-16/h14,16-18,33H,2-13H2,1H3,(H,27,32)(H,24,25,26)/t17-,18+/m1/s1
Canonical SMILES:
CC1=NC(=C(C(=N1)NNC(=O)C(CC2CCCC2)CN(C=O)O)F)N3CCN4CCOCC4C3
Current Developer:
Originator:GlaxoSmithKline
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

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