Landiolol - CAS 133242-30-5
Catalog number:
133242-30-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C25H39N3O8
Molecular Weight:
509.60
COA:
Inquire
Targets:
Adrenergic Receptor
Description:
Landiolol is an ultra-short-acting Beta 1 adrenergic receptor antagonist using for managing supraventricular tachyarrhythmias in sepsis. It is also used as an anti-arrhythmic agent.
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Purity:
> 95%
Appearance:
Powder
Synonyms:
Ono 1101; UNII-62NWQ924LH; [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate;144481-98-1(hydrochloride)
Solubility:
Soluble in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
antiarrhythmic agent
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
InChIKey:
WMDSZGFJQKSLLH-RBBKRZOGSA-N
InChI:
1S/C25H39N3O8/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31)/t20-,22+/m0/s1
Canonical SMILES:
C1(OC[C@H](O1)COC(CCc1ccc(OC[C@H](CNCCNC(N2CCOCC2)=O)O)cc1)=O)(C)C
Current Developer:
Originator Ono Pharmaceutical
1.[A Case of Undiagnosed Extra-adrenal Pheochromocytoma in an Adult Patient with Single Ventricle Circulation after the Bidirectional Glenn Operation].
Kohno M, Nagamine Y, Goto T. Masui. 2015 Sep;64(9):985-8.
We experienced a case of undiagnosed extra-adrenal pheochromocytoma in an adult patient with single ventricle circulation after the bidirectional Glenn operation. A 32-year-old woman was scheduled for open abdominal surgery for incidental retroperitoneal tumor. She had undergone the bidirectional Glenn operation for complex congenital heart disease consisting of double outlet right ventricle, ventricular septal defect, and pulmonary artery stenosis. She had not undergone the Fontan operation because of insufficient development of pulmonary circulation. Her physical status was New York Heart Association (NYHA) functional class II, and her oxygen saturation was 80% in room air. She reported no symptoms for the abdominal tumor preoperatively. The surgery was performed under general and epidural anesthesia. After induction of general anesthesia, she developed hypertension and tachycardia, and the manipulation of the tumor worsened them. Landiolol, a short acting beta blocker, and nicardipine were administrated.
2.[Usefullness of Beta-blocker for Hemodynamic Changes Induced by Uterotonic Drug in a Patient with Hypertrophic Obstructive Cardiomyopathy Undergoing Elective Cesarean Section].
Tsukano Y, Sugita M, Ikuta Y, Yamamoto T. Masui. 2015 Jun;64(6):642-6.
Combined spinal-epidural anesthesia (CSEA) was given to a 27-year-old woman with hypertrophic obstructive cardiomyopathy (HOCM) for a selective cesarean section. After the injection of uterotonic drug via uterine muscle and a vein after delivery, the patient developed dyspnea, tachycardia, ST-change on elecrocardiogram and hypotension. It is important in HOCM patients to control heart rate and left ventricular contractile force. We started to infuse beta-blocker (landiolol, 10 μg x kg(-1) x min(-1)) and improved these symptoms of the patient. This case demonstrates that CSEA is safe for HOCM patients and beta-blocker is effective to improve hemodynamic changes induced by uterotonic drug in these patients.
3.Efficacy and Safety of Landiolol Compared to Amiodarone for the Management of Postoperative Atrial Fibrillation in Intensive Care Patients.
Shibata SC1, Uchiyama A2, Ohta N2, Fujino Y2. J Cardiothorac Vasc Anesth. 2016 Apr;30(2):418-22. doi: 10.1053/j.jvca.2015.09.007. Epub 2015 Sep 25.
OBJECTIVE: The authors assessed the efficacy and safety of landiolol, an ultra-short-acting beta-blocker, with those of amiodarone in the restoration of sinus rhythm for postoperative atrial fibrillation (POAF) in intensive care unit (ICU) patients.
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CAS 133242-30-5 Landiolol

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