1.[Effect of lactic acid bacteria isolated from Tibetan Plateau on silage fermentation quality of Elms nutans].
Zhang H, Ke W, Jing P, Zhang J, Chen M, Yu Y, Guo X. Wei Sheng Wu Xue Bao. 2015 Oct 4;55(10):1291-7.
OBJECTIVE: In order to detect the effect of lactic acid bacteria isolated from Tibetan Plateau on silage fermentation quality of Elms nutans.
2.Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro.
Makarević J1, Tsaur I2, Juengel E1, Borgmann H1, Nelson K3, Thomas C1, Bartsch G1, Haferkamp A1, Blaheta RA1. Life Sci. 2016 Feb 15;147:137-42. doi: 10.1016/j.lfs.2016.01.039. Epub 2016 Jan 29.
AIMS: Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicine the potential of this natural, widely used substance to exert antineoplastic effects on prostate cancer cells has been assessed.
3.[In vitro microdialysis recoveries of nine active ingredients in Mahuang decoction].
Tang YH, Wan HT, Chen JZ, Zhou HF, Tian YF, He Y. Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(18):3667-73.
To detect the in vitro probe microdialysis recoveries based on an HPLC-DAD method for simultaneous quantification of nine active ingredients (ephedrine, pseudoephedrine, methylephedrine, amygdalin, liquiritin, cinnamyl alcohol, cinnamic acid, cinnamaldehyde and glycyrrhizic acid) in Mahuang decoction, which provides reference for in vivo pharmacokinetic study. The concentrations of nine active ingredients in dialysate were detected by HPLC-DAD, to investigate the effect of flow rates (incremental method and subtraction method) and intraday stability of the probe recoveries and medium concentrations on the recoveries. Nine active ingredients could be well separated in 52 min. At the perfusion rate of 1.0 μL x min(-1), the relative recoveries of ephedrine, pseudoephedrine, methylephedrine, amygdalin, liquiritin, cinnamyl alcohol, cinnamic acid, cinnamaldehyde and glycyrrhizic acid were (50.95 ± 0.82)%, (52.74 ± 1.13)%, (51.29 ± 0.51)%, (32.
4.Pharmacokinetics, Safety, and Tolerability of Amygdalin and Paeoniflorin After Single and Multiple Intravenous Infusions of Huoxue-Tongluo Lyophilized Powder for Injection in Healthy Chinese Volunteers.
Li X1, Shi F2, Zhang R2, Sun C2, Gong C2, Jian L3, Ding L4. Clin Ther. 2016 Feb;38(2):327-37. doi: 10.1016/j.clinthera.2015.12.005. Epub 2015 Dec 31.
PURPOSE: Huoxue-Tongluo lyophilized powder for injection (HTLPI), a traditional Chinese medicine preparation, is a compound of Persicae semen and Paeoniae Radix Rubra that is used mainly for treating blood-stasis obstruction syndrome in the acute stage of cerebral ischemic stroke. Amygdalin (AD) and paeoniflorin (PF) are 2 typical bioactive components in HTLPI and were selected as indicators for this pharmacokinetic study of HTLPI. The objective of this study was to investigate the safety profile, tolerability, and pharmacokinetic properties of AD and PF after single and multiple intravenous infusions of HTLPI in healthy Chinese volunteers.