|Description||Ladostigil, also called as TV-3,326, is a novel neuroprotective agent developed to treat neurodegenerative disorders sunch as Alzheimer’s disease. Ladostigil is a dual acetylcholine-butyrylcholineesterase and brain selective monoamine oxidase (MAO)-A and -B inhibitor in vivo (with little or no MAO inhibitory effect in the liver and small intestine).|
|Synonyms||[(3R)-3-(prop-2-ynylamino)-2,3-dihydro-1H-inden-5-yl] N-ethyl-N-methylcarbamate; (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate; Ladostigil; TV 3326; TV3326|
Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.
The hydrochloride salt form of CI 1002, an azepinoquinazoline derivative, has been found to be an acetylcholinesterase inhibitor that could probably be effectiv...
BT-11, the extract of dried root of Polygala tenuifolia Willdenow, is an orally available LANCL2 binding compound for treating inflammatory bowel disease. In ad...
AP2238 is a inhibitor of both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Drofenine hydrochloride is a widely used anticholinergic acts on smooth muscle to stop muscle spasms.
Galanthamine, also called Razadyne, found in GALANTHUS and other AMARYLLIDACEAE, a cholinesterase inhibitor prescribed to treat symptoms of mild to moderate Alz...
Pralidoxime is an antidote to organophosphate pesticides, reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organoph...
(-)-Huperzine A (HupA)
(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G...
The hydrochloride salt of Protriptyline which is a norepinephrine uptake blocker that could be effective as an antidepressant.
Pyridostigmine is a parasympathomimetic and a reversible cholinesterase inhibitor.
Ladostigil, also called as TV-3,326, is a novel neuroprotective agent developed to treat neurodegenerative disorders sunch as Alzheimer’s disease. Ladostigil is...
Neostigmine methyl sulfate is a cholinesterase inhibitor used in the treatment of myasthenia gravis, can not cross the blood-brain barrier.
Donepezil, also called Aricept, a centrally acting reversible acetyl cholinesterase inhibitor that the FDA has also approved for the treatment of moderate to se...
Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.
Edrophonium chloride is a reversible Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine compe...
Reversible AChE inhibitor. D2 receptor antagonist. Raises motilin and somatostatin levels. Lowers CCK levels. Shows gastroprokinetic effects in vivo. Orally act...
Edrophonium is a reversible Acetylcholinesterase inhibitor which is effective in avoiding the decomposition of the neurotransmitter acetylcholine competitively ...
Galantamine is a competitive and reversible cholinesterase(AChE) inhibitor, which is used for the treatment of mild to moderate Alzheimer's disease and various ...
Pipenzolate, a muscarinic receptor antagonist, commonly existed as bromide salt form and could be used as a spasmolytic and could probably effective in aid ther...
Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.