labetalol hydrochloride - CAS 32780-64-6
Catalog number: 32780-64-6
Category: Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H25ClN2O3
Molecular Weight:
364.87
COA:
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Targets:
Adrenergic Receptor
Description:
Labetalol HCl is a dual antagonist for both selective alpha1-adrenergic and nonselective beta-adrenergic receptors, used in the treatment of high blood pressure.
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Purity:
>98%
Synonyms:
labetalol hydrochloride
MSDS:
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1.MIBG Activity in the Gallbladder.
Bai X1, Zhuang H. Clin Nucl Med. 2016 Feb 24. [Epub ahead of print]
Whole-body I-MIBG images were acquired in a 12-year-old girl who had metastatic malignant paraganglioma to assess the extent of the metastases. Image quality was suboptimal because of diffusely increased muscle activity, which was related to the labetalol the patient took to control her blood pressure. Despite the suboptimal images, a subtle activity in the lower border of the liver was noted, along with known lesions in the sacrum and upper chest. Further SPECT/CT images localized this activity in the gallbladder.
2.Risks of parenteral antihypertensive therapy for the treatment of severe maternal hypertension are low.
Sharma KJ1, Rodriguez M1, Kilpatrick SJ1, Greene N1, Aghajanian P1. Hypertens Pregnancy. 2016 Feb;35(1):123-8. doi: 10.3109/10641955.2015.1117098. Epub 2016 Feb 24.
OBJECTIVE: To determine whether the incidence of hypotension or adverse fetal heart tracing (FHT) category change differed following antepartum administration of intravenous (IV) labetalol versus hydralazine.
3.When barriers ignore the "rule-of-five".
Krämer SD1, Aschmann HE2, Hatibovic M2, Hermann KF2, Neuhaus CS2, Brunner C2, Belli S3. Adv Drug Deliv Rev. 2016 Feb 12. pii: S0169-409X(16)30051-5. doi: 10.1016/j.addr.2016.02.001. [Epub ahead of print]
Why are a few drugs with properties beyond the rule of 5 (bRo5) absorbed across the intestinal mucosa while most other bRo5 compounds are not? Are such exceptional bRo5 compounds exclusively taken up by carrier-mediated transport or are they able to permeate the lipid bilayer (passive lipoidal diffusion)? Our experimental data with liposomes indicate that tetracycline, which violates one rule of the Ro5, and rifampicin, violating three of the rules, significantly permeate a phospholipid bilayer with kinetics similar to labetalol and metoprolol, respectively. Published data from experimental work and molecular dynamics simulations suggest that the formation of intramolecular H-bonds and the possibility to adopt an elongated shape besides the presence of a significant fraction of net neutral species facilitate lipid bilayer permeation. As an alternative to lipid bilayer permeation, carrier proteins can be targeted to improve absorption, with the potential drawbacks of drug-drug interactions and non-linear pharmacokinetics.
4.Maternal ethnicity and its impact on the haemodynamic and blood pressure response to labetalol for the treatment of antenatal hypertension.
Stott D1, Bolten M1, Paraschiv D1, Papastefanou I2, Chambers JB3, Kametas NA4. Open Heart. 2016 Mar 22;3(1):e000351. doi: 10.1136/openhrt-2015-000351. eCollection 2016.
OBJECTIVE: Blood pressure (BP) control outside pregnancy is associated with a reduction in adverse cardiovascular events, and in pregnancy with improved outcomes. Outside pregnancy, there is evidence β-blockers are less effective in controlling BP in black populations. However, in pregnancy, labetalol is recommended as a universal first-line treatment, without evidence for the impact of ethnicity on its efficacy. We sought to compare haemodynamic responses to labetalol in black and white pregnant patients.
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CAS 32780-64-6 labetalol hydrochloride

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