Labetalol - CAS 36894-69-6
Catalog number:
36894-69-6
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C19H24N2O3
Molecular Weight:
328.41
COA:
Inquire
Targets:
Others
Description:
Labetalol is a competitive antagonist of both α- and β-adrenoreceptors that is used to treat high blood pressure.
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Purity:
≥98%
Appearance:
White solid
Synonyms:
labetalol;Labetolol;Albetol;Normodyne;36894-69-6;Labetalolum
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
A mixed alpha/beta adrenergic antagonist
Quality Standard:
Enterprise standard/USP
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly.
Quantity:
Grams-Kilos
Boiling Point:
552.7ºC at 760 mmHg
Density:
1.2 g/cm3
InChIKey:
SGUAFYQXFOLMHL-UHFFFAOYSA-N
InChI:
1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24)
Canonical SMILES:
CC(CCC1=CC=CC=C1)NCC(C2=CC(=C(C=C2)O)C(=O)N)O
1.Evaluating the Potential Severity of Look-Alike, Sound-Alike Drug Substitution Errors in Children.
Basco WT Jr1, Garner SS2, Ebeling M3, Freeland KD3, Hulsey TC4, Simpson K5. Acad Pediatr. 2016 Mar;16(2):183-91. doi: 10.1016/j.acap.2015.06.014. Epub 2015 Sep 26.
OBJECTIVE: Look-alike, sound-alike (LASA) drug name substitution errors in children may pose potentially severe consequences. Our objective was to determine the degree of potential harm pediatricians ascribe to specific ambulatory LASA drug substitution errors.
2.When barriers ignore the "rule-of-five".
Krämer SD1, Aschmann HE2, Hatibovic M2, Hermann KF2, Neuhaus CS2, Brunner C2, Belli S3. Adv Drug Deliv Rev. 2016 Feb 12. pii: S0169-409X(16)30051-5. doi: 10.1016/j.addr.2016.02.001. [Epub ahead of print]
Why are a few drugs with properties beyond the rule of 5 (bRo5) absorbed across the intestinal mucosa while most other bRo5 compounds are not? Are such exceptional bRo5 compounds exclusively taken up by carrier-mediated transport or are they able to permeate the lipid bilayer (passive lipoidal diffusion)? Our experimental data with liposomes indicate that tetracycline, which violates one rule of the Ro5, and rifampicin, violating three of the rules, significantly permeate a phospholipid bilayer with kinetics similar to labetalol and metoprolol, respectively. Published data from experimental work and molecular dynamics simulations suggest that the formation of intramolecular H-bonds and the possibility to adopt an elongated shape besides the presence of a significant fraction of net neutral species facilitate lipid bilayer permeation. As an alternative to lipid bilayer permeation, carrier proteins can be targeted to improve absorption, with the potential drawbacks of drug-drug interactions and non-linear pharmacokinetics.
3.Risks of parenteral antihypertensive therapy for the treatment of severe maternal hypertension are low.
Sharma KJ1, Rodriguez M1, Kilpatrick SJ1, Greene N1, Aghajanian P1. Hypertens Pregnancy. 2016 Feb;35(1):123-8. doi: 10.3109/10641955.2015.1117098. Epub 2016 Feb 24.
OBJECTIVE: To determine whether the incidence of hypotension or adverse fetal heart tracing (FHT) category change differed following antepartum administration of intravenous (IV) labetalol versus hydralazine.
4.MIBG Activity in the Gallbladder.
Bai X1, Zhuang H. Clin Nucl Med. 2016 Feb 24. [Epub ahead of print]
Whole-body I-MIBG images were acquired in a 12-year-old girl who had metastatic malignant paraganglioma to assess the extent of the metastases. Image quality was suboptimal because of diffusely increased muscle activity, which was related to the labetalol the patient took to control her blood pressure. Despite the suboptimal images, a subtle activity in the lower border of the liver was noted, along with known lesions in the sacrum and upper chest. Further SPECT/CT images localized this activity in the gallbladder.
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CAS 36894-69-6 Labetalol

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