L791943 - CAS 192767-01-4
Category: Inhibitor
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Molecular Formula:
C24H17F10NO4
Molecular Weight:
573.38
COA:
Inquire
Targets:
Phosphodiesterase (PDE)
Description:
L791943 is a highly potent and metabolically stable PDE4 inhibitor with good in vitro activity (IC50= 4.2 nM). L-791, 943 is potent in vitro and in vivo as demonstrated by the inhibition of antigen-induced bronchoconstriction in a variety of models.The compound is well absorbed and is well tolerated in the ferret.
Synonyms:
L791943; L 791943; L-791943; 2-[4-[1-[3,4-bis(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol; L-791,943; L-791943
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
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Boiling Point:
561.6±50.0 ℃ at 760 Torr
Density:
1.44±0.1 g/cm3
InChIKey:
VIOWRSXFEPSZFI-UHFFFAOYSA-N
InChI:
1S/C24H17F10NO4/c25-20(26)38-18-6-3-15(12-19(18)39-21(27)28)17(11-13-7-9-35(37)10-8-13)14-1-4-16(5-2-14)22(36,23(29,30)31)24(32,33)34/h1-10,12,17,20-21,36H,11H2
Canonical SMILES:
C1=CC(=CC=C1C(CC2=CC=[N+](C=C2)[O-])C3=CC(=C(C=C3)OC(F)F)OC(F)F)C(C(F)(F)F)(C(F)(F)F)O
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CAS 192767-01-4 L791943

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