L-NMMA acetate - CAS 53308-83-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Nitric oxide synthase (NOS)
L-NMMA is the archetypal competitive NOS inhibitor of all three NOS isoforms.
≥98% by HPLC
L-NMMA acetate; L NMMA acetate; LNMMA acetate; ANO-1020; ANO 1020; ANO1020; Tilarginine acetate; NG-Monomethyl-L-arginine acetate;
Canonical SMILES:
1.Autophagy activation by interferon-γ via the p38 mitogen-activated protein kinase signalling pathway is involved in macrophage bactericidal activity.
Matsuzawa T1, Fujiwara E, Washi Y. Immunology. 2014 Jan;141(1):61-9. doi: 10.1111/imm.12168.
Macrophages are involved in many essential immune functions. Their role in cell-autonomous innate immunity is reinforced by interferon-γ (IFN-γ), which is mainly secreted by proliferating type 1 T helper cells and natural killer cells. Previously, we showed that IFN-γ activates autophagy via p38 mitogen-activated protein kinase (p38 MAPK), but the biological importance of this signalling pathway has not been clear. Here, we found that macrophage bactericidal activity increased by 4 hr after IFN-γ stimulation. Inducible nitric oxide synthase (NOS2) is a major downstream effector of the Janus kinase-signal transducer and activator of transcription 1 signalling pathway that contributes to macrophage bactericidal activity via nitric oxide (NO) generation. However, no NO generation was observed after 4 hr of IFN-γ stimulation, and macrophage bactericidal activity at early stages after IFN-γ stimulation was not affected by the NOS inhibitors, NG-methyl-l-arginine acetate salt and diphenyleneiodonium chloride.
2.Inhibition of phosphate-induced apoptosis in resting zone chondrocytes by thrombin peptide 508.
Zhong M1, Carney DH, Ryaby JT, Schwartz Z, Boyan BD. Cells Tissues Organs. 2009;189(1-4):56-9. doi: 10.1159/000152913. Epub 2008 Sep 1.
Growth plate chondrocytes are susceptible to apoptosis. Terminally differentiated chondrocytes are deleted via apoptosis, which primes the growth plate to vascular invasion and subsequent bone formation. Whether less differentiated resting zone chondrocytes are subject to the same mechanism that governs the apoptotic pathway of more differentiated growth zone chondrocytes is not known. In our current study, we demonstrated that inorganic phosphate, a key inducer of growth plate chondrocyte apoptosis, also causes apoptosis in resting zone chondrocytes, via a pathway similar to the one in growth zone chondrocytes. Our results demonstrated that the conditions that cause growth plate chondrocyte apoptosis lie in the external environment, instead of the differences in differentiation state.
3.Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury.
Egemnazarov B1, Sydykov A, Schermuly RT, Weissmann N, Stasch JP, Sarybaev AS, Seeger W, Grimminger F, Ghofrani HA. Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L462-9. doi: 10.1152/ajplung.90377.2008. Epub 2008 Dec 12.
The protective effects of nitric oxide (NO), a physiological activator of soluble guanylyl cyclase (sGC), have been reported in ischemia-reperfusion (I/R) syndrome of the lung. Therefore, we studied the effects of BAY 41-2272, a novel sGC stimulator, on I/R injury of the lung in an isolated intact organ model. Lung injury was assessed by measuring weight gain and microvascular permeability (capillary filtration coefficient, K(fc)). Release of reactive oxygen species (ROS) into the perfusate was measured during early reperfusion by electron spin resonance (ESR) spectroscopy. Rabbit lungs were treated with BAY 41-2272, N(G)-monomethyl-L-arginine (L-NMMA), or NO to evaluate the effects on I/R-induced lung injury. In untreated lungs, a dramatic rise in K(fc) values and weight gain during reperfusion were observed, and these results were associated with increased ROS production. Both, BAY 41-2272 and L-NMMA significantly attenuated vascular leakage and suppressed ROS release.
4.Angiotensin II type 2 receptor-mediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo.
Brouwers S1, Smolders I, Massie A, Dupont AG. Hypertension. 2013 Nov;62(5):920-6. doi: 10.1161/HYPERTENSIONAHA.112.00762. Epub 2013 Sep 16.
Angiotensin II type 2 receptor (AT2R)-mediated vasodilation has been demonstrated in different vascular beds in vitro and in perfused organs. In vivo studies, however, consistently failed to disclose renal vasodilator responses to compound 21, a selective AT2R agonist, even after angiotensin II type 1 receptor blockade. Here, we investigated in vivo whether angiotensin-converting enzyme inhibition, reducing endogenous angiotensin II levels, could unmask the effects of selective AT2R stimulation on blood pressure and renal hemodynamics in normotensive and hypertensive rats. After pretreatment with the angiotensin-converting enzyme inhibitor captopril, intravenous administration of compound 21 did not affect blood pressure and induced dose-dependent renal vasodilator responses in spontaneously hypertensive but not in normotensive rats. The D1 receptor agonist fenoldopam, used as positive control, reduced blood pressure and renal vascular resistance in both strains.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Nitric oxide synthase (NOS) Products

CAS 180001-34-7 1400W

(CAS: 180001-34-7)

1400W is a selective inducible nitric oxide synthase (NOS) inhibitor(Ki=7nM,IC50=2.0uM).By suppressing the induction of inducible NOS, 1400W exhibits an therape...

CAS 74209-34-0 3-Bromo-7-nitroindazole

(CAS: 74209-34-0)

3-Bromo-7-nitroindazole has been found to be a nNOS inhibitor and could also be a neuroprotective compound that inhibits the endoplasmic reticulum stress pathwa...

Cindunistat hydrochloride maleate
(CAS: 753491-31-5)

Cindunistat is a selective Nitric oxide synthase (iNOS) type II inhibitor. It is potentially useful in patients with symptomatic osteoarthritis of the knee. But...

CAS 1937-19-5 Aminoguanidine hydrochloride

Aminoguanidine hydrochloride
(CAS: 1937-19-5)

Aminoguanidine hydrochloride is the hydrochloride salt form of Aminoguanidine. Aminoguanidine is an inhibitor that has an irreversible function on iNOS with sel...

CAS 771-97-1 2,3-Diaminonaphthalene

(CAS: 771-97-1)

2,3 Diaminonaphthalene is a highly selective colorimetric and fluorometric reagent for selenium detection and also an inhibitor of nitric oxide (NO) formation.

CAS 30344-00-4 SDMA

(CAS: 30344-00-4)

An endogenous inhibitor of nitric oxide (NO) synthase activity

CAS 62949-77-3 Kuwanon A

Kuwanon A
(CAS: 62949-77-3)

Kuwanon A, a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.), inhibits nitric oxide production (IC50= 10.5 μM).

(CAS: 206885-38-3)

Ronopterin is a potent Nitric oxide synthase inhibitor used as a neuroprotectant.

Chemical Structure

CAS 53308-83-1 L-NMMA acetate

Quick Inquiry

Verification code

Featured Items