L-NAME HCl - CAS 51298-62-5
Catalog number:
51298-62-5
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C7H15N5O4.HCl
Molecular Weight:
269.69
COA:
Inquire
Targets:
Others
Description:
L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively.
Publictions citing BOC Sciences Products
  • >> More
Purity:
>98%
Synonyms:
Nω-Nitro-L-arginine methyl ester hydrochloride
MSDS:
Inquire
1.Effect of low doses of L-NAME on methamphetamine-induced dopaminergic depletion in the rat striatum
T. Abekawa, T. Ohmori, M. Honda. J Neural Transm (2001) 108: 1219–1230
NO-mediated neurotoxicity is induced by reaction with superoxide (O2-), leading to formation of neurotoxic substance, peroxynitrite (ONOO) (Radi et al., 1991). We (Abekawa et al., 1996) have shown that a high dose of a non-selective eNOS and nNOS inhibitor, L-NAME (30mg/kg, i.p., 2) significantly reduced the METH-induced decreases in contents of dopamine and its metabolites in the striatum. Consistent with our report, several groups revealed that not only high doses of L-NAME (37, 75, 150, and 300mg/kg 2) but also high doses of a nNOS selective NOS inhibitor, 7-NI (25mg/kg 3 or 50mg/kg 4) attenuated the METH-induced dopaminergic neurotoxicity in the striatum of mice (Di Monte et al., 1996; Itzhak and Ali, 1996; Taraska and Finnegan, 1997). Recently, Itzhak et al. (1998) reported that nNOSdeficient mice were resistant to the METH-induced neurotoxicity. These findings suggest that the METH-induced dopaminergic neurotoxicity is mediated by nNOS-producing NO.
2.Effect of L-arginine methyl ester (L-NAME) on hormonal profile and estrous cycle length in buffaloes (Bubalus bubalis)
Pushp Sagar & Jai Kishan Prasad & Shiv Prasad. Trop Anim Health Prod (2012) 44:1697–1702
Nitric oxide is involved in the regulation of corpus luteum (CL) function and life span depending on the stage of CL development (Motta et al. 2001). At the early stage of CL development, nitric oxide promotes progesterone production (Tamanini et al. 2003), but at mid and late luteal phase, it inhibits progesterone production. Nitric oxide is a potent luteolytic agent synthesized in the body from L-arginine through the action of enzyme nitric oxide synthase. The formation of nitric acid is an oxygen and NADPHdependant reaction. There are several drugs like 7-nitro indazole (Ivana et al. 2002), N-phenylamidines (Suaifan et al. 2010) and L-arginine methyl ester (L-NAME) (Dariusz et al. 2003) which inhibit the nitric oxide concentration by checking the nitric oxide synthase enzyme. The involvement of L-NAME for PGF-induced luteolysis has been documented in cattle (Dariusz et al. 2003), but the studies are lacking in buffaloes. The objective of the present study was to evaluate the effect of L-NAME administration on the blood serum concentrations of progesterone and estrogen, the life span of the CL and the length of the estrous cycle in buffaloes.
3.L-NAME has Opposite Effects on the Productions of S-adenosylhomocysteine and S-adenosylmethionine in V12-H-Ras and M-CR3B-Ras Pheochromocytoma Cells
Maia Sephashvili, Elene Zhuravliova. Neurochem Res (2006) 31:1205–1210
Significant alterations of methyl cycle metabolites were observed under action of L-NAME. It was found that the content of SAM in MCR cells in the presence of L-NAME was increased, whereas the synthesis of SAM in the MVR cells was greatly reduced. And vice versa, in the MCR cells accumulation of SAM under action of L-NAME was decreased, while the production of SAH significantly rose. These opposite changes showed that MVR cells differ from MCR on sensitivity to constitutional levels of nitric oxide, that apparently act on the oncogenic and normal Ras by distinct ways.
4.Acute impairment of rat renal function by l-NAME as measured using dynamic MRI
Farid Sari-Sarraf, Silvia Pomposiello, Didier Laurent. Magn Reson Mater Phy (2008) 21:291–297
The present study assessed whether dynamic MRI is a suitable method for measuring changes in renal function in a rat model with acute hypertension in response to the nitric oxide (NO) synthase inhibitor NG-nitro-l-arginine methylester (l-NAME). Nitric oxide (NO) is an endothelium-dependent vasodilatorwhichissynthesizedinresponsetovariousstimuli, and when released at the vicinity of glomeruli, increases blood flow resulting in increased GFR and urine formation. Inhibiting NO synthesis with l-NAME leads to an increase in blood pressure through vasoconstriction of vascular smooth muscle cells and reduction in renal blood flow, which leads to decreased GFR and sodium excretion.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 17560-51-9 Metolazone

Metolazone
(CAS: 17560-51-9)

Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, which results in the decreases of blood volume and the increa...

GYKI-23107 dihydrochloride
(CAS: 83843-39-4)

GYKI-23107 is an antiarrhythmic agent with local anaesthetic activity.

BMS-214662 mesylate
(CAS: 474010-58-7)

BMS-214662 mesylate is a potent and selective inhibitor of farnesyltransferase that induces mitochondrial apoptosis in chronic myeloid leukemia stem/progenitor ...

Ingenol-5,20-acetonide
(CAS: 77573-43-4)

Ingenol-5,20-acetonide is extracted from the seeds of Euphorbia lathyris L. It is an analogue of Ingenol 3-Angelate. It is used as an intermediate for synthesis...

CAS 1672-46-4 Digoxigenin

Digoxigenin
(CAS: 1672-46-4)

Digoxigenin is a steroid probe to detect different viruses in many molecular biology applications.

CAS 4394-00-7 Niflumic Acid

Niflumic Acid
(CAS: 4394-00-7)

A selective COX-2 inhibitor; GPR35 activator; Cox-2: IC50 = 918 nM (human); Cox-1: IC50 = 1.06 µM (human); GPR35: IC50 = 1.28 µM (human)

CAS 1421227-52-2 WS3

WS3
(CAS: 1421227-52-2)

WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM.

DiZPK
(CAS: 1337883-32-5)

DiZPK, a photocrosslinking amino acid, could be significant in revealling the physiological and functions of some proteins acting as a genetically encoded.

CAS 113962-61-1 Cgp 13231

Cgp 13231
(CAS: 113962-61-1)

Cgp 13231 is the N-oxide metabolite of amocarzine

CAS 83-40-9 3-Methylsalicylic acid

3-Methylsalicylic acid
(CAS: 83-40-9)

3-Methylsalicylic acid has marked fibrinolytic activity in human plasma by activating its fibrinolytic system. It is a salicylic acid derivative compound, which...

CAS 29679-58-1 Fenoprofen

Fenoprofen
(CAS: 29679-58-1)

Fenoprofen is a non-steroidal anti-inflammatory drug, act as an anti-inflammatory analgesic and antipyretic highly bound to plasma proteins.

CAS 63333-35-7 Bromethalin

Bromethalin
(CAS: 63333-35-7)

Bromethalin is a new rodenticide for the control of commensal rodents.

TAK-243
(CAS: 1450833-55-2)

TAK-243, a pyrazolopyrimidine derivative, has been found to be an Ubiquitin-protein ligase inhibitor and was just finished the Phase-I trial against solid tumou...

RG7800
(CAS: 1449598-06-4)

RG7800 is a selective Survival of motor neuron 1 protein (SMN1) stimulant and Survival of motor neuron 2 protein (SMN2) modulator originated by Roche. RG7800 sh...

CAS 15574-49-9 Mecarbinate

Mecarbinate
(CAS: 15574-49-9)

Mecarbinate is a chemical intermediate of arbidol hydrochloride.

Paritaprevir
(CAS: 1216941-48-8)

Paritaprevir could inhibit viral phosphoprotein NS5A and is significant to viral replication and other activities. It also has been found to have potential effe...

CAS 132-65-0 Dibenzothiophene

Dibenzothiophene
(CAS: 132-65-0)

Dibenzothiophene (DBT) is a model compound for organic sulfur in fossil fuels.

CAS 74397-12-9 Limaprost

Limaprost
(CAS: 74397-12-9)

Limaprost is a potent platelet adhesion inhibitor and vasodilator that increases blood flow and inhibits platelet aggregation. It is an analog of prostaglandin ...

CAS 6233-83-6 Oxytocin acetate

Oxytocin acetate
(CAS: 6233-83-6)

Oxytocin acetate is a mammalian neurohypophysial hormone. Its actions are mediated by specific, high-affinity oxytocin receptors. Oxytocin is normally produced ...

CAS 144675-97-8 Pixantrone Maleate

Pixantrone Maleate
(CAS: 144675-97-8)

Pixantrone is a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topo...

Chemical Structure

CAS 51298-62-5 L-NAME HCl

Quick Inquiry

Verification code

Featured Items