L-α-Methyltyrosine - CAS 672-87-7
Catalog number:
672-87-7
Category:
Inhibitor
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C10H13NO3
Molecular Weight:
195.21
COA:
Inquire
Description:
L-α-Methyltyrosine is a tyrosine hydroxylase inhibitor. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. It reduces the elevated levels of catecholamines associated with pheochromocytoma, thus preventing hypertension.
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Purity:
98%
Appearance:
White Solid
Synonyms:
α-Methyl-L-tyrosine;(S)-2-(4-Hydroxybenzyl)-2-aminopropanoic Acid;(S)-α-Methyltyrosine;Demser;L(-)-Metyrosine;L-α-MT;Metirosine;(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid;Racemetirosine
Solubility:
Boiling Methanol, Water
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
L-α-Methyltyrosine is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma.
Quality Standard:
In-house standard
Quantity:
Grams to Kilograms
Boiling Point:
383.7±32.0 °C | Condition: Press: 760 Torr
Melting Point:
312.5 °C
Density:
1.283±0.06 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
NHTGHBARYWONDQ-JTQLQIEISA-N
InChI:
InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
Canonical SMILES:
CC(CC1=CC=C(C=C1)O)(C(=O)O)N
1.Kinetics of 3-[(123)I]iodo-l-alpha-methyltyrosine transport in rat C6 glioma cells.
Riemann B1, Stögbauer F, Kopka K, Halfter H, Lasic M, Schirmacher A, Kuwert T, Weckesser M, Ringelstein EB, Schober O. Eur J Nucl Med. 1999 Oct;26(10):1274-8.
3-[(123)I]Iodo-l-alpha-methyltyrosine ((123)I-IMT) is used for the diagnosis and monitoring of brain tumours by means of single-photon emission tomography (SPET). To date, little has been known about the system for the transport of (123)I-IMT into brain tumour cells. It is assumed that (123)I-IMT is transported by a specific carrier for large, neutral amino acids (L-system). In this study, rat C6 glioma cells were used to characterize the uptake system of (123)I-IMT and to investigate its precise kinetics. The time course of (123)I-IMT uptake into the cells was examined for a range of 1-60 min. (123)I-IMT uptake rates with varying concentrations of (123)I-IMT (2. 5-50 microM) in the medium were quantified to assess the kinetic parameters of (123)I-IMT transport. Furthermore, competition of (123)I-IMT with other amino acids was investigated to identify the distinct transport systems involved in (123)I-IMT uptake. (123)I-IMT uptake into C6 glioma cells was linear for approximately 10 min and reached a steady-state level within 30 min.
2.Noninvasive grading of untreated gliomas: a comparative study of MR imaging and 3-(iodine 123)-L-alpha-methyltyrosine SPECT.
Riemann B1, Papke K, Hoess N, Kuwert T, Weckesser M, Matheja P, Wassmann H, Heindel W, Schober O. Radiology. 2002 Nov;225(2):567-74.
PURPOSE: To compare the accuracy of magnetic resonance (MR) imaging scores with that of 3-(iodine 123)-L-alpha-methyltyrosine ((123)I-IMT) single photon emission computed tomography (SPECT) in the noninvasive grading of untreated gliomas.
3.Expression of L amino acid transport system 1 and analysis of iodine-123-methyltyrosine tumor uptake in a pancreatic xenotransplantation model using fused high-resolution-micro-SPECT-MRI.
von Forstner C1, Zuhayra M, Ammerpohl O, Zhao Y, Tiwari S, Jansen O, Kalthoff H, Henze E, Egberts JH. Hepatobiliary Pancreat Dis Int. 2011 Feb;10(1):30-7.
BACKGROUND: The specificity in discriminating pancreatitis is limited in the positron emission tomography (PET) using Fluorine-18-fluorodeoxyglucose. Furthermore, PET is not widely available compared to the single photon emission computed tomography (SPECT). Since amino acids play a minor role in metabolism of inflammatory cells, the potential of the SPECT tracer, 3-[123I]iodo-L-alpha-methyltyrosine (123I-IMT), for detecting pancreatic cancer was examined in xenotransplantation models of human pancreatic carcinoma in mice.
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CAS 672-87-7 L-α-Methyltyrosine

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