L-Glutamine-5-13C - CAS 159680-32-7
Molecular Formula:
H2N[13C]O(CH2)2CH(NH2)COOH
Molecular Weight:
147.14
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Tag:
Free Amino Acids & Derivatives (Labelled)
Description:
L-Glutamine-5-13C is a labelled L-Glutamine. Glutamine is an α-amino acid used in the biosynthesis of proteins.
Purity:
98% by HPLC; 99% atom 13C
Related CAS:
56-85-9 (unlabelled)
Synonyms:
Acustasin-13C; Stimulina-13C; Cebrogen-13C; Levoglutamide-13C; (2S)-2,5-diamino-5-oxopentanoic acid-13C
MSDS:
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InChIKey:
ZDXPYRJPNDTMRX-MYXYCAHRSA-N
InChI:
InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1/i4+1
Canonical SMILES:
C(CC(=O)N)C(C(=O)O)N
1.Mass isotopomer study of glutamine oxidation and synthesis in primary culture of astrocytes.
Lee WN1, Edmond J, Bassilian S, Morrow JW. Dev Neurosci. 1996;18(5-6):469-77.
The metabolism of [1, 2-13C2] acetate via the tricarboxylic acid (TCA) cycle leads to the formation of a number of key mass isotopomers of glutamate. The distribution of these isotopomers which is a function of pyruvate carboxylase, pyruvate dehydrogenase and pyruvate recycling was used to determine the relative anaplerotic flux and glutamine oxidation of astrocytes in culture under different substrate conditions. Combinatory analysis of mass isotopomers formed from the condensation of labeled oxaloacetate with labeled acetyl-CoA was used to determine precursor enrichment and fractional glutamine synthesis. When glucose or glutamine was supplied in the medium, the effective anaplerotic flux (Y') was about 1.5 times that of the TCA cycle flux. Under substrate-limiting conditions, Y' and glutamine synthesis was significantly reduced. A unique feature of the use of [1, 2-13C2] acetate in this study is the formation of singly labeled isotopomer of glutamine in the C4 or C5 position when glutamine is irreversibly loss in net oxidation.
2.Leucine and glutamine metabolism in septic rats.
Yoshida S1, Lanza-Jacoby S, Stein TP. Biochem J. 1991 Jun 1;276 ( Pt 2):405-9.
The rate of leucine C-2 incorporation into glutamine was compared in control and septic rats. Female Sprague-Dawley rats (n = 46, 210-260 g) were fed parenterally for 3 days and then randomized into two groups (control and septic). Sepsis was induced by the injection of 10(10) live Escherichia coli/kg on day 4 into the septic group. Rats in each group were given a continuous (8 h) infusion of one of three different isotopes. The isotopes were given 24 h after inoculation. Leucine oxidation and incorporation into protein were determined with [1-13C]leucine; glutamine flux and oxidation were determined with [5-13C]glutamine, and the fraction of leucine C-2 incorporated into glutamine was determined by giving [1,2-13C]leucine. Results were as follows: sepsis caused a significant increase in the rate of leucine C-2 incorporation into glutamine (66.0 +/- 3.7 as against 29.6 +/- 3.7 mumol/h per kg, P less than 0.01). This increase was due to both an increase in glutamine production (2331 +/- 76 as against 1959 +/- 94 mumol/h per kg, P less than 0.
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Chemical Structure

CAS 159680-32-7 L-Glutamine-5-13C

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